N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide

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N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide manufacturers

  • JNJ-9350
  • JNJ-9350 pictures
  • 2026-07-14
  • CAS:326923-09-5
  • Purity: 98.56%
  • Supply Ability: 10g
N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide Basic information
Product Name:N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide
Synonyms:TOSLAB 794812;Pyrazolo[1,5-a]pyrimidine-2-carboxamide, N-[3-(1H-imidazol-1-yl)propyl]-5,7-diphenyl-;JNJ-9350;N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS:326923-09-5
MF:C25H22N6O
MW:422.48
EINECS:
Product Categories:
Mol File:Mol File
N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide Structure
N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide Chemical Properties
density 1.28±0.1 g/cm3(Predicted)
solubility DMSO: Sparingly Soluble: 1-10 mg/ml
Methanol: Slightly Soluble: 0.1-1 mg/ml
form Solid
pka10.08±0.46(Predicted)
color White to light brown
Safety Information
MSDS Information
N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide Usage And Synthesis
UsesJNJ-9350 is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1].
in vivo
1.19Pharmacokinetic Properties of JNJ-9350 in Mice [1].
Mice
PO 10 mg/kg
Clearance (mL/min/kg) (Total/Unbound)73/5217
Volume of distribution (L/kg)1.7
Half-life (min)16
PPB (Mouse)98.6%
Oral F%34%
References[1] SMOx PROBE PROPOSAL
[2] CÉCILE BECQUART. Exploring Heterocycle-Spermine Conjugates as Modulators of Oncogenic microRNAs Biogenesis[J]. ACS Omega, 2018, 3 12: 16500-16508. DOI: 10.1021/acsomega.8b02681
N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide Preparation Products And Raw materials
Tag:N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide(326923-09-5) Related Product Information
N-(3-(1H-Imidazol-1-yl)propyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-2-carboxamide JNJ-42226314 JNJ-10198409 JNJ 26483327 JNJ-47117096 (trifluoroacetate salt) JNJ-38158471