JNJ-10198409 manufacturers
- JNJ-10198409
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- $29.00
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2026-08-03
- CAS:627518-40-5
- Purity: 99.15%
- Supply Ability: 10g
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| | JNJ-10198409 Basic information |
| Product Name: | JNJ-10198409 | | Synonyms: | PDGFR Tyrosine Kinase Inhibitor IV;JNJ-10198409 (This product is only available in Japan.);N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;JNJ-10198409;Indeno[1,2-c]pyrazol-3-amine, N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-;RWJ 540973, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine;JNJ-10198409, Free Base;3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine | | CAS: | 627518-40-5 | | MF: | C18H16FN3O2 | | MW: | 325.34 | | EINECS: | | | Product Categories: | | | Mol File: | 627518-40-5.mol |  |
| | JNJ-10198409 Chemical Properties |
| Melting point | 171-173.5 °C | | Boiling point | 528.8±50.0 °C(Predicted) | | density | 1.366±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: >10mg/mL | | form | solid | | pka | 14.01±0.20(Predicted) | | color | off-white | | InChI | 1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) | | InChIKey | ZDNURMVOKAERHZ-UHFFFAOYSA-N | | SMILES | COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | JNJ-10198409 Usage And Synthesis |
| Uses | JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM)[1][2]. | | Biological Activity | jnj-10198409 is a small molecule inhibitor of platelet-derived growth factor (pdgf-bb) tyrosine kinase [1].platelet-derived growth factor (pdgf) is a ubiquitous mitogen involved in regulating cell growth and division, embryonic development, cell proliferation, cell migration, and angiogenesis. overexpression of pdgf has been associated with several diseases such as atherosclerosis, fibrotic disorders and malignancies. inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (pdgf-bb) receptor can have potent antiangiogenic and antiproliferative activity. recombinant pdgf is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry to treat bone loss [2].in human coronary artery smooth muscle cells, jnj-10198409 inhibited the activity of platelet-derived growth factor (pdgf-bb) tyrosine kinase with an ic50 value of 4.2 nm when tested. jnj-10198409 was a competitive antagonist of the atp binding and hydrolysis at pdgf-bb receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis [1]. | | IC 50 | PDGFRβ: 4.2 nM (IC50); PDGFRα: 45 nM (IC50) | | storage | Store at -20°C | | references | [1] ho c y, ludovici d w, maharoof u s m, et al. (6, 7-dimethoxy-2, 4-dihydroindeno [1, 2-c] pyrazol-3-yl) phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells[j]. journal of medicinal chemistry, 2005, 48(26): 8163-8173.
[2] raines e w, bowen-pope d f, ross r. platelet-derived growth factor[m]//peptide growth factors and their receptors i. springer berlin heidelberg, 1990: 173-262. |
| | JNJ-10198409 Preparation Products And Raw materials |
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