4-Formyl-2-isopropylthiazole manufacturers
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| | 4-Formyl-2-isopropylthiazole Basic information |
| Product Name: | 4-Formyl-2-isopropylthiazole | | Synonyms: | 4-Thiazolecarboxaldehyde, 2-(1-methylethyl)- (9CI);2-isopropylthiazole-4-carbaldehyde;2-(propan-2-yl)-1,3-thiazole-4-carbaldehyde;2-isopropylthiazol-4-carbaldehyde;2-(1-methylethyl)-4-Thiazolecarboxaldehyde;4-Thiazolecarboxaldehyde, 2-(1-methylethyl)-;4-FORMYL-2-ISOPROPYLTHIAZOLE | | CAS: | 133047-46-8 | | MF: | C7H9NOS | | MW: | 155.22 | | EINECS: | 604-604-1 | | Product Categories: | ALDEHYDE;ISOPROPYL | | Mol File: | 133047-46-8.mol |  |
| | 4-Formyl-2-isopropylthiazole Chemical Properties |
| Boiling point | 232.4±13.0 °C(Predicted) | | density | 1.159±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 1.10±0.10(Predicted) | | Appearance | Light yellow to yellow Liquid | | InChI | InChI=1S/C7H9NOS/c1-5(2)7-8-6(3-9)4-10-7/h3-5H,1-2H3 | | InChIKey | NUEZKCPTDMEROB-UHFFFAOYSA-N | | SMILES | S1C=C(C=O)N=C1C(C)C |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HS Code | 2934100090 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 4-Formyl-2-isopropylthiazole Usage And Synthesis |
| Synthesis | A solution of 3.1 g (15.6 mmol) of ethyl 2-isopropylthiazole-4-carboxylate in 50 ml of dichloromethane was cooled under N2 atmosphere to -78° C and treated dropwise with 15.6 ml (23.4 mmol) of a 1.5 M solution of diisobutylaluminum hydride in toluene over 1.5 h. After being stirred for an additional 0.5 h, the solution was quenched with 5 ml of methanol followed by 15 ml of aqueous Rochelle's salt. The resulting mixture was partitioned between chloroform and aqueous Rochelle's salt, dried over Na2SO4, and concentrated to provide 1.37 g (56 %) of the crude 4-Formyl-2-isopropylthiazole. | | References | [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 14, p. 2319 - 2332
[2] Patent: US2005/131017, 2005, A1. Location in patent: Page/Page column 141
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 602 - 617
[4] Patent: US6528510, 2003, B1
[5] Patent: US6251906, 2001, B1 |
| | 4-Formyl-2-isopropylthiazole Preparation Products And Raw materials |
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