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| | 15(R)-ILOPROST Basic information |
| Product Name: | 15(R)-ILOPROST | | Synonyms: | 6,9ALPHA-METHYLENE-11ALPHA,15R-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID;15(R)-ILOPROST;HIFJCPQKFCZDDL-GAGQTBDJSA-N;Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-, (5E)- (9CI);15(R)-IloprostQ: What is
15(R)-Iloprost Q: What is the CAS Number of
15(R)-Iloprost | | CAS: | 85026-51-3 | | MF: | C22H32O4 | | MW: | 360.49 | | EINECS: | | | Product Categories: | | | Mol File: | 85026-51-3.mol |  |
| | 15(R)-ILOPROST Chemical Properties |
| solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml |
| | 15(R)-ILOPROST Usage And Synthesis |
| Description | Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM. 15(R)-Iloprost is the “unnatural” or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. There are no literature reports of the biological activity of 15(R)-iloprost. | | Uses | 15(R)-Iloprost is the unnatural or inverted C-15 epimer of lloprost (HY-A0096)[1]. | | References | [1] W J van der Giessen, et al. The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig. Thromb Res. 1984 Oct 1;36(1):45-51. DOI:10.1016/0049-3848(84)90375-x |
| | 15(R)-ILOPROST Preparation Products And Raw materials |
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