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| | 5-FLUORO-2-HYDROXYMETHYL PYRIDINE Basic information |
| Product Name: | 5-FLUORO-2-HYDROXYMETHYL PYRIDINE | | Synonyms: | 5-FLUORO-2-HYDROXYMETHYL PYRIDINE;5-Fluoro-2-hydroxymethyl ...;5-Fluoropyridine-2-methanol;(5-fluoro-2-pyridinyl)methanol;5-fluoro-2-Pyridinemethanol;(5-Fluoropyridin-2-yl);EOS-60647;2-Pyridinemethanol, 5-fluoro- | | CAS: | 802325-29-7 | | MF: | C6H6FNO | | MW: | 127.12 | | EINECS: | | | Product Categories: | | | Mol File: | 802325-29-7.mol |  |
| | 5-FLUORO-2-HYDROXYMETHYL PYRIDINE Chemical Properties |
| Boiling point | 200.4±25.0 °C(Predicted) | | density | 1.262±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 13.08±0.10(Predicted) | | Appearance | Light yellow to brown Liquid |
| | 5-FLUORO-2-HYDROXYMETHYL PYRIDINE Usage And Synthesis |
| Uses | 5-Fluoro-2-hydroxymethylpyridine | | Synthesis | General procedure for the synthesis of (5-fluoropyridin-2-yl)methanol from ethyl 5-fluoropyridine-2-carboxylate: to a solution of ethyl 5-fluoropyridine-2-carboxylate (377 mg, 2.23 mmol) in tetrahydrofuran (6 mL) was slowly added lithium aluminum hydride (LiAlH4, 73 mg, 3.34 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, it was quenched with ice water and the organic layer was subsequently extracted with ethyl acetate. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with ethyl acetate/hexane (20:80 to 60:40) as eluent to give (5-fluoropyridin-2-yl)methanol (309 mg, 54% yield, colorless oil). | | References | [1] Patent: WO2008/8398, 2008, A2. Location in patent: Page/Page column 354
[2] Patent: EP1748048, 2007, A1. Location in patent: Page/Page column 35 |
| | 5-FLUORO-2-HYDROXYMETHYL PYRIDINE Preparation Products And Raw materials |
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