1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)-
| 中文名称 | 1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)- |
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| 中文同义词 | 化合物 T16851;化合物 SB-267268;1H-2-苯并氮卓-4-乙酸,2,3,4,5-四氢-3-氧代-8-[3-(2-吡啶基氨基)丙氧基]-2-(2,2,2-三氟乙基)-(4S)- |
| 英文名称 | 1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)- |
| 英文同义词 | 1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)-;SB-267268;SB267268,SB 267268 |
| CAS号 | 205678-26-8 |
| 分子式 | C22H24F3N3O4 |
| 分子量 | 451.44 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 205678-26-8.mol |
| 结构式 | ![1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)- 结构式](CAS/20210111/GIF/205678-26-8.gif) |
1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)- 性质
| 沸点 | 677.2±55.0 °C(Predicted) |
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| 密度 | 1.320±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.32±0.10(Predicted) |
| 形态 | Solid |
| 颜色 | White to off-white |
1H-2-Benzazepine-4-acetic acid, 2,3,4,5-tetrahydro-3-oxo-8-[3-(2-pyridinylamino)propoxy]-2-(2,2,2-trifluoroethyl)-, (4S)- 用途与合成方法
SB-267268 was much less potent for inhibition of human, mouse, and ratαvβ6 integrin. SB-267268 inhibits the attachment of bothαvβ3-transfected HEK293 cells to microtiter plate wells precoated with arginine-glycine-aspartic acid (RGD)-containing matrix proteins with IC 50 values of 12 nM. SB-267268 also inhibits vitronectin-mediated human and rat aortic smooth-muscle-cell (SMC) migration with IC 50 values of approximately 12.3 nM and 3.6 nM, respectively.
SB-267268 (60 mg/kg; bi-daily, i.p.) reduces blood vessel profiles (BVPs) in the inner retina by 50%.
In ROP mice treated with SB-267268, VEGF and VEGFR-2 gene expression in the inner nuclear layer (INL) and the ganglion cell layer (GCL) is reduced.
| Animal Model: | Pregnant female C57BL/6 mice (ROP mice) |
| Dosage: | 60 mg/kg |
| Administration: | I.p.; bi-daily |
| Result: | Reduced blood vessel profiles (BVPs) in the inner retina by 50%. |