| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
DSHN >=98% (HPLC) manufacturers
- DSHN
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- $1980.00
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2026-05-21
- CAS:313952-63-5
- Purity:
- Supply Ability: 10g
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| | DSHN >=98% (HPLC) Basic information |
| Product Name: | DSHN >=98% (HPLC) | | Synonyms: | DSHN >=98% (HPLC);2-Naphthalenecarboxylic acid, 5-[(diethylamino)sulfonyl]-3-hydroxy-;5-(N,N-Diethylsulfamoyl)-3-hydroxy-2-naphthoic acid | | CAS: | 313952-63-5 | | MF: | C15H17NO5S | | MW: | 323.36 | | EINECS: | | | Product Categories: | | | Mol File: | 313952-63-5.mol |  |
| | DSHN >=98% (HPLC) Chemical Properties |
| Boiling point | 519.7±60.0 °C(Predicted) | | density | 1.387±0.06 g/cm3(Predicted) | | pka | 2.73±0.30(Predicted) |
| | DSHN >=98% (HPLC) Usage And Synthesis |
| Description | DSHN is a novel activator of small heterodimer partner (SHP, NR0B2). DSHN transcriptionally activates SHP mRNA, but also stabilizes the SHP protein by preventing its ubiquitination and degradation. | | Uses | DSHN is a potent small heterodimer partner (SHP) activator. DSHN inhibits Ccl2 expression and secretion by inhibiting p65 activation of Ccl2 promoter activity. DSHN can be used in research of cancer[1]. | | Definition | ChEBI: 5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid is a member of naphthalenes and a sulfonic acid derivative. | | in vivo | DSHN transcriptionally activated Shp mRNA, but also stabilized the SHP protein by preventing its ubiquitination and degradation. Second, this study identified Ccl2 as a new SHP target gene by RNA-seq. This study showed that activation of SHP by DSHN repressed Ccl2 expression and secretion by inhibiting p65 activation of CCL2 promoter activity, as demonstrated in vivo in Shp-/- mice and in vitro in HCC cells with SHP overexpression and knockdown._x000D_
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Reference: Mol Cancer Ther. 2016 Oct;15(10):2294-2301. https://pubmed.ncbi.nlm.nih.gov/27486225/ | | target | DSHN is a novel activator of small heterodimer partner (SHP, NR0B2). | | References | [1] Yang Z, et, al. A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2. Mol Cancer Ther. 2016 Oct;15(10):2294-2301. DOI:10.1158/1535-7163.MCT-16-0153 |
| | DSHN >=98% (HPLC) Preparation Products And Raw materials |
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