- 4-Aminophthalide
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- $1.00
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2020-01-10
- CAS:59434-19-4
- Min. Order: 1KG
- Purity: 98% HPLC
- Supply Ability: 10 tons/month
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| | 4-Aminophthalide Basic information |
| | 4-Aminophthalide Chemical Properties |
| Melting point | 154-155 °C | | Boiling point | 411.0±45.0 °C(Predicted) | | density | 1.376 | | storage temp. | 2-8°C, protect from light | | pka | 2.70±0.20(Predicted) | | Appearance | Off-white to light brown Solid |
| | 4-Aminophthalide Usage And Synthesis |
| Uses | 4-Aminophthalide acts as a reagent in the synthesis of butylphthalide derivatives with medical applications. | | Synthesis | General procedure for the synthesis of 4-aminoisobenzofuran-1(3H)-one from 4-nitroisobenzofuran-1(3H)-one: 4-nitroisobenzofuran-1(3H)-one (1.0 g, 5.58 mmol) and 10% Pd/C (0.1 g) were suspended in ethyl acetate (30 mL). The reaction system was purged with hydrogen (1 atm) and stirred for 3 hours at 25°C. After completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated to afford 4-aminoisobenzofuran-1(3H)-one (0.8 g, 96% yield) as an off-white solid. Mass spectrum (ESI) m/z: 150 (M + 1)+. 1H-NMR (400 MHz, CDCl3) δ 3.82 (s, broad peak, 1H), 5.19 (s, 3H), 6.91-6.95 (m, 1H), 7.32-7.36 (m, 2H). | | References | [1] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 84-85
[3] Journal fuer Praktische Chemie/Chemiker-Zeitung, 1993, vol. 335, # 1, p. 17 - 22
[4] Advanced Synthesis and Catalysis, 2010, vol. 352, # 11-12, p. 1834 - 1840
[5] Chemistry - A European Journal, 2011, vol. 17, # 21, p. 5903 - 5907 |
| | 4-Aminophthalide Preparation Products And Raw materials |
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