ChemicalBook > Product Catalog >Organic Chemistry >Hydrazine or hydroxylamine derivatives >(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate

(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate

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(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Basic information
Product Name:(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
Synonyms:sodium (2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate;FPI-1523 sodium;sodium (2S,5R)-N'-acetyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide
CAS:1452459-52-7
MF:C9H15N4NaO7S
MW:346.29
EINECS:
Product Categories:
Mol File:1452459-52-7.mol
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Structure
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Usage And Synthesis
UsesFPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].
References[1] King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8. DOI:10.1021/acschembio.5b00944
(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Preparation Products And Raw materials
Tag:(2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate(1452459-52-7) Related Product Information
AvibactaM Avibactam Impurity (2S,5R)-2-(2-acetylhydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate Zidebactam (1R,2S,5R)-7-oxo-2-(2-((S)-piperidine- 3-carbonyl)hydrazine-1-carbonyl) -1,6- diazabi cyclo[3.2.1]octan-6-yl hydrogen sulfate sodium (2S,5R)-2-(2-(2-cyanoacetyl)hydrazine-1-carbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate