| Company Name: |
Shanghai Beiwanta Biotechnology Co., Ltd. Gold
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| Tel: |
021-67187366 19901745723 |
| Email: |
info@bwtlab.com |
| Products Intro: |
Product Name:6β-hydroxy Testosterone
CAS:62-99-7
Purity:99% HPLC Package:1mg;5mg
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| | 6BETA-HYDROXYTESTOSTERONE Basic information |
| Product Name: | 6BETA-HYDROXYTESTOSTERONE | | Synonyms: | 6B hydroxytestosterone--dea schedule*iii item;6BETA-HYDROXYTESTOSERONE;6,7-Dihydroxy-6b,17b-androst-4-en-one ;(6R,8R,9S,10R,13S,14S,17S)-6,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;6,7-Dihydroxy-6,17-androst-4-en-one;4-ANDROSTEN-6-BETA, 17-BETA-DIOL-3-ONE;4-ANDROSTENE-6BETA,17BETA-DIOL-3-ONE;6BETA-HYDROXYTESTOSTERONE | | CAS: | 62-99-7 | | MF: | C19H28O3 | | MW: | 304.42 | | EINECS: | 636-305-6 | | Product Categories: | Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals;Steroids;Metabolites & Impurities | | Mol File: | 62-99-7.mol |  |
| | 6BETA-HYDROXYTESTOSTERONE Chemical Properties |
| Melting point | ≥205 °C | | Boiling point | 479.8±45.0 °C(Predicted) | | density | 1.19±0.1 g/cm3(Predicted) | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml | | form | A crystalline solid | | pka | 13.98±0.70(Predicted) | | color | white to off-white | | Major Application | clinical testing | | InChI | 1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1 | | InChIKey | XSEGWEUVSZRCBC-ZVBLRVHNSA-N | | SMILES | C[C@]12CC[C@H]3[C@@H](C[C@@H](O)C4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O |
| Hazard Codes | Xn,T,F | | Risk Statements | 61-40-39/23/24/25-23/24/25-11 | | Safety Statements | 53-22-36/37/39-45-36/37-16-7 | | RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | | WGK Germany | 3 | | HS Code | 29372290 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 |
| | 6BETA-HYDROXYTESTOSTERONE Usage And Synthesis |
| Description | CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens. They mediate the metabolism of xenobiotics as well as certain endobiotics, including steroid hormones. CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens. They mediate the metabolism of xenobiotics as well as certain endobiotics, including steroid hormones. 6β-hydroxy Testosterone is a major metabolite produced from testosterone by the actions of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed from testosterone. The biological effects of 6β-hydroxy testosterone have been poorly studied. | | Chemical Properties | White Solid | | Uses | A metabolite of Testosterone (T155000).
CONTROLLED SUBSTANCE | | Uses | A metabolite of Testosterone.
CONTROLLED SUBSTANC | | Definition | ChEBI: A 17beta-hydroxy steroid that is testosterone bearing an additional hydroxy substituent at the 6beta-position. | | General Description | A Certified Spiking Solution suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from clinical and diagnostic testing to endocrinology and sports testing. 6-Hydroxytestosterone is a major urinary metabolite of testosterone, a hormone from the androgen group of steroids. Testosterone is an important sex hormone and anabolic steroid used as a performance-enhancing drug. | | References | [1] BETH W COOPER. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression.[J]. Toxicological Sciences, 2008, 103 2: 268-277. DOI: 10.1093/toxsci/kfn047
[2] A J DRAPER. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes.[J]. Drug Metabolism and Disposition, 1998, 26 4: 299-304.
[3] JORGE H. CAPDEVILA. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.[J]. The Journal of Biological Chemistry, 1990, 24 1: 10865-10871. DOI: 10.1016/s0021-9258(19)38526-6
[4] ATHAR HUSAIN . Herb–drug interaction studies of ethanolic extract of Cassia occidentalis L. coadministered with acetaminophen, theophylline, omeprazole, methotrexate and methylprednisolone[J]. Phytomedicine Plus, 2021, 1 1: Article 100008. DOI: 10.1016/j.phyplu.2020.100008 |
| | 6BETA-HYDROXYTESTOSTERONE Preparation Products And Raw materials |
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