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Loperamide

Loperamide Suppliers list
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Loperamide manufacturers

Loperamide Basic information
Product Name:Loperamide
Synonyms:loperamide oxide;R 58425;trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutanamide 1-oxide;trans-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide 1-oxide monohydrate;Loperamide EP Impurity F;4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide N-oxide;LoperaMide-d6 N-Oxide;Loperamide impurity-F(EP)
CAS:106900-12-3
MF:C29H33ClN2O3
MW:493.04
EINECS:
Product Categories:Amines;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals
Mol File:106900-12-3.mol
Loperamide Structure
Loperamide Chemical Properties
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in alcohol and in methylene chloride.
pka12.94±0.20(Predicted)
form powder
Stability:Hygroscopic
Major Applicationpharmaceutical
InChI1S/C29H33ClN2O3/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32(35)20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
InChIKeyKXVSBTJVTUVNPM-UHFFFAOYSA-N
SMILESClc1ccc(cc1)C2(CC[N](=O)(CC2)CCC(c4ccccc4)(c3ccccc3)C(=O)N(C)C)O
Safety Information
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 1
RTECS TM4960200
HS Code 2933399090
Storage Class6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
MSDS Information
Loperamide Usage And Synthesis
Chemical PropertiesWhite or almost white powder, slightly hygroscopic.
UsesLoperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
UsesLabelled Loperamide oxide (LOPOX). It is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperamide in jejunum and colon.
DefinitionChEBI: Loperamide oxide is a diarylmethane.
Loperamide Preparation Products And Raw materials
Tag:Loperamide(106900-12-3) Related Product Information
Desmethyl loperamide 1-(4-Chloro-phenyl)-3-dimethylamino-propan-1-ol (R)-1-(4-Chlorophenyl)-1-propanol Triethylamine N-oxide 2,2-Diphenylpropylamine hydrochloride Trimethylamine N-oxide fenpipramide 4-(4-CHLOROPHENYL)PIPERIDINE Alverine 4-(4-Chlorophenyl)piperidin-4-ol (Diphenyl-3,3 propyl)-1 phenyl-4 piperidine chlorhydrate [French] Loperamide Trimethylamine N-oxide dihydrate DIPHENAMID Loperamide