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| | S-(2-thiopyridyl)mercaptopropionohydrazide Basic information |
| | S-(2-thiopyridyl)mercaptopropionohydrazide Chemical Properties |
| Melting point | 87-90°C | | Boiling point | 463.6±41.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.81±0.35(Predicted) | | color | White | | Stability: | Light Sensitive | | InChI | 1S/C8H11N3OS2/c9-11-7(12)4-6-13-14-8-3-1-2-5-10-8/h1-3,5H,4,6,9H2,(H,11,12) | | InChIKey | NITXODYAMWZEJY-UHFFFAOYSA-N | | SMILES | NNC(CCSSC1=NC=CC=C1)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | S-(2-thiopyridyl)mercaptopropionohydrazide Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | A fluorescent sulfhydryl active reagent. | | General Description | The PDPH is a heterobifunctional crosslinker containing sulfhydryl-reactive pyridyldithiol and carbonyl-reactive hydrazide moieties. Pyridyldithiols react with free sulfhydryls (-SH) to form disulfide bonds. Hydrazide groups react with carbonyls (aldehydes and ketones) to form stable hydrazone bonds. Aldehyde groups can be created by periodate-oxidation of sialic acid and other sugar components of glycoprotein polysaccharides. Thus, PDPH is useful for conjugating glycoproteins and sulfhydryl-containing peptides or proteins. Likewise, PDPH is useful as a sulfhydryl-addition reagent for glycoproteins and other carbohydrates; after reaction of the hydrazide to an oxidized carbohydrate, the pyridyldithiol group can be cleaved by a reducing agent to expose a sulfhydryl group. Yet another application for PDPH is to react the primary amine of the hydrazide moiety to a carboxyl group using the crosslinker EDC. | | reaction suitability | reagent type: cross-linking reagent |
| | S-(2-thiopyridyl)mercaptopropionohydrazide Preparation Products And Raw materials |
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