熊去氧胆酸杂质24
| 中文名称 | 熊去氧胆酸杂质24 |
|---|---|
| 中文同义词 | 24-去甲熊去氧胆酸(NOR-UDCA);24-去甲氧基胆酸;化合物24-NORURSODEOXYCHOLIC ACID;熊去氧胆酸杂质24;24-去氧胆酸;24-去甲熊去氧胆酸;(R)-3-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-二羟基-10,13-二甲基十六氢-1H-环戊并[A]菲-17-基]丁酸;24-去甲熊脱氧胆酸 |
| 英文名称 | 24-norursodeoxycholic acid |
| 英文同义词 | 24-norursodeoxycholic acid;(3α,5β,7β)-3,7-Dihydroxy-24-norcholan-23-oic Acid;3α,7β-Dihydroxy-24-nor-5β-cholan-23-oic Acid;Norursodeoxycholic Acid;nor-UDCA;Urosodeoxycholic Acid Impurity 24;24-Norursodeoxycholic acid,24Norursodeoxycholic acid,Inhibitor,Norucholic acid,24 Norursodeoxycholic acid,inhibit;24-Norcholan-23-oic acid, 3,7-dihydroxy-, (3α,5β,7β)- |
| CAS号 | 99697-24-2 |
| 分子式 | C23H38O4 |
| 分子量 | 378.55 |
| EINECS号 | |
| 相关类别 | 抑制剂;胆酸系列;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
| Mol文件 | 99697-24-2.mol |
| 结构式 |  |
熊去氧胆酸杂质24 性质
| 熔点 | 117 - 123°C |
|---|---|
| 沸点 | 536.7±25.0 °C(Predicted) |
| 密度 | 1.142±0.06 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | DMSO（微溶）、乙醇（微溶）、甲醇（微溶） |
| 酸度系数(pKa) | 4.71±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 灰白色至浅黄色 |
| InChIKey | QYYDXDSPYPOWRO-JHMCBHKWSA-N |
| SMILES | O[C@@H]1[C@@H]2[C@@H]([C@@]4([C@H](C1)C[C@@H](CC4)O)C)CC[C@]3([C@H]2CC[C@@H]3[C@@H](CC(=O)O)C)C |
24-norursodeoxycholic acid (norUDCA) 是侧链缩短的 UDCA 的 C23 同系物，具有有效的抗胆汁淤积，抗炎和抗纤维化特性。
24-norursodeoxycholic acid (norUDCA) is a side chain-shortened C23 homologue of UDCA and is previously shown to be highly effective in preclinical mouse models of cholestatic and fibrotic liver diseases. 24-norursodeoxycholic acid significantly reduces serum alkaline phosphatase (ALP) levels in a dose-dependent fashion. 24-norursodeoxycholic acid also significantly reduces γ-GT, ALT, and AST serum levels.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-101737 | 熊去氧胆酸杂质24 24-Norursodeoxycholic acid | 99697-24-2 | 1mg | 280元 |
| 2025/12/22 | HY-101737 | 熊去氧胆酸杂质24 24-Norursodeoxycholic acid | 99697-24-2 | 5mg | 700元 |
上游原料