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| | epidermin Basic information |
| Product Name: | epidermin | | Synonyms: | epidermin;PubChem ID: 16132391;L-Cysteinamide, L-isoleucyl-L-alanyl-D-cysteinyl-L-lysyl-L-phenylalanyl-L-isoleucyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-lysyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-, cyc...;L-Cysteinamide, L-isoleucyl-L-alanyl-D-cysteinyl-L-lysyl-L-phenylalanyl-L-isoleucyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-prolylglycyl-L-cysteinyl-L-alanyl-L-lysyl-(2Z)-2-amino-2-butenoylglycyl-D-cysteinyl-L-phenylalanyl-L-asparaginyl-D-cysteinyl-L-tyrosyl-N-[(1Z)-2-mercaptoethenyl]-, cyclic (3→7),(8→11),(16→21),(19→21)-tetrakis(thioether) | | CAS: | 99165-17-0 | | MF: | C98H141N25O23S4 | | MW: | 2165.59 | | EINECS: | | | Product Categories: | | | Mol File: | 99165-17-0.mol |  |
| | epidermin Chemical Properties |
| density | 1.41±0.1 g/cm3(Predicted) | | pka | 9.89±0.15(Predicted) |
| | epidermin Usage And Synthesis |
| Description |
Epidermin is defined as a lantibiotic produced by S. epidermidis, which is a thioether amino acid–containing antimicrobial peptide active against various bacteria, contributing to bacterial interference and colonization on human skin.
| | Synthesis |
Solid-phase peptide synthesis of epidermin:epidermin is synthesized in the ribosome via a precursor protein, followed by enzymatic modifications. It was isolated from the culture filtrate of Staphylococcus epidermidis TU 3298 by adsorption on Amberlite XAD-8. The basic heneicosapeptide amide was chromatographed on Sephadex LH-20 and purified to homogeneity via multiplicative counter-current distributions in one acidic and one neutral system.
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| | epidermin Preparation Products And Raw materials |
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