| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
|
| | SK&F 75670 Basic information |
| | SK&F 75670 Chemical Properties |
| solubility | DMSO: soluble 12mg/mL
H2O: insoluble | | form | Solid | | color | White to yellow | | InChI | 1S/C17H19NO2.BrH/c1-18-8-7-13-9-16(19)17(20)10-14(13)15(11-18)12-5-3-2-4-6-12;/h2-6,9-10,15,19-20H,7-8,11H2,1H3;1H | | InChIKey | KWTPHNVUAVFKGB-UHFFFAOYSA-N | | SMILES | Br.CN1CCc2cc(O)c(O)cc2C(C1)c3ccccc3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | SK&F 75670 Usage And Synthesis |
| Uses | SKF-75670 hydrobromide is an atypical D1 dopamine receptor agonist. | | Biological Activity | SKF-75670 is a selective dopamine D1 receptor agonist but with lower efficacy. It also acts as cocaine antagonist and alters the behavioral effects of cocaine in squirrel monkeys.', 'Atypical D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo. | | in vivo | SKF-75670 hydrochloride (2.5-10 mg/kg, i.p.) reduces locomotor activity in MPTP-treated marmosets[2].
SKF-75670 hydrochloride (0.3 and 1.0 mg/kg, i.m.) antagonizes the rate-altering and discriminative-stimulus effects of Cocaine in monkeys[3].
| Animal Model: | MPTP-treated marmosets[2] | | Dosage: | 2.5-10 mg/kg | | Administration: | i.p. | | Result: | Reduced locomotor activity (marmosets were largely immobile and appeared sedated and had a flexed posture). |
| | IC 50 | D1 Receptor |
| | SK&F 75670 Preparation Products And Raw materials |
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