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SKF-38393 (hydrobromide) manufacturers
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| | SKF-38393 (hydrobromide) Basic information |
| Product Name: | SKF-38393 (hydrobromide) | | Synonyms: | 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol:hydrobromide;SKF-38393 HBr;SKF 38393;SKF38393;SKF-38393;SKF 38393 hydrobromide - Bio-X | | CAS: | 20012-10-6 | | MF: | C16H18BrNO2 | | MW: | 336.23 | | EINECS: | | | Product Categories: | API | | Mol File: | 20012-10-6.mol |  |
| | SKF-38393 (hydrobromide) Chemical Properties |
| Melting point | 283-285 °C | | storage temp. | Desiccate at -20°C | | solubility | Soluble to 25 mM in water with gentle warming and to 25 mM in ethanol with gentle warming | | form | Powder | | color | White |
| | SKF-38393 (hydrobromide) Usage And Synthesis |
| Uses | SKF 38393 Hydrobromide is a derivative of a unique dopamine receptor agonist. | | in vivo | SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
| Animal Model: | Balb/c mice (20-25 g)[3] | | Dosage: | 5 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine. |
| | IC 50 | D1 Receptor: 110 nM (IC50) | | storage | -20°C (desiccate) |
| | SKF-38393 (hydrobromide) Preparation Products And Raw materials |
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