| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
BAY-805 manufacturers
- BAY-805
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- $1920.00
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2026-05-11
- CAS:2925481-88-3
- Purity: 99.49%
- Supply Ability: 10g
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| | BAY-805 Basic information |
| Product Name: | BAY-805 | | Synonyms: | BAY-805;(R)-BAY-728;Cyclohexanecarboxamide, N-[(1R)-1-[[[5-[(4-cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)-;BAY 805 New;CAS:2925481-88-3 | | CAS: | 2925481-88-3 | | MF: | C24H28F3N5O2S | | MW: | 507.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2925481-88-3.mol |  |
| | BAY-805 Chemical Properties |
| density | 1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 2mg/mL, clear | | pka | 8.17±0.50(predicted) | | form | Solid | | color | White to off-white |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | BAY-805 Usage And Synthesis |
| Uses | BAY-805 is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes[1]. | | Biological Activity | Potent and selective dual USP21 deubiquitinase (DUB) inhibitor with anti-cancer efficacy.
BAY-805 is a higly potent and selective USP21 deubiquitinase (DUBs) inhibitor (IC50 (Emax) = 6 nM (95%) by HTRF assay, 2 nM (87%) by Ub-Rh110 assay; Kd = 2.2 nM by SPR-based competition assay; 50/53% inhibition of USP10/USP22 at 10 μM, <31% inhibition against other DUBs) th at effectively upregulates cellular NF-KB activation (7-fold increase at 10 μM 20h post BAY-805 treatment by HEK293T-based reporter assay) with good target engagement (EC50 = 17 nM by USP21 HiBiT CESTA assay). | | References | [1] Gricke F, et al. Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. J Med Chem. 2023 Feb 20. DOI:10.1021/acs.jmedchem.2c01933 |
| | BAY-805 Preparation Products And Raw materials |
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