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- NSC697923
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- $39.00
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2026-07-27
- CAS:343351-67-7
- Purity: 99.84%
- Supply Ability: 10g
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| Product Name: | NSC697923 | | Synonyms: | Furan, 2-[(4-Methylphenyl)sulfonyl]-5-nitro-;NSC697923;2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran;2-Nitro-5-tosylfuran;2-Nitro-5-(toluene-4-sulfonyl)-furan;2-[(4-Methylphenyl)sulfonyl]-5-nitrofur;NSC697923 USP/EP/BP;NSC697923, UBE2N inhibitor | | CAS: | 343351-67-7 | | MF: | C11H9NO5S | | MW: | 267.25786 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 343351-67-7.mol |  |
| | NSC697923 Chemical Properties |
| Melting point | 124-126°C | | Boiling point | 443.8±40.0 °C(Predicted) | | density | 1.416±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | InChI | 1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3 | | InChIKey | GAUHIPWCDXOLCZ-UHFFFAOYSA-N | | SMILES | [S](=O)(=O)(c2[o]c(cc2)[N+](=O)[O-])c1ccc(cc1)C |
| Hazard Codes | Xn | | Risk Statements | 22-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | NSC697923 Usage And Synthesis |
| Description | NSC-69723 (343351-67-7) is a selective inhibitor of the E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3Induces neuroblastoma cell death via activation of p53 and JNK.4 | | Uses | NSC 697923 is a cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A and exhibits potent cytotoxicity in a panel of Neuroblastoma (NB) cell lines. NSC 697923 also inhibits the proliferation and survival of diffuse large B-cell lymphoma cells (DLBCL). | | in vivo | NSC697923 (5mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts[1]. | Animal Model: | 5- to 6-week-old female athymic Ncr nude mice (orthotopic mouse model of NB; SH-SY5Y and NGP xenografts)[1] | | Dosage: | 5mg/kg | | Administration: | I.p.; daily for 10 days | | Result: | Significant tumor regression in both SH-SY5Y and NGP xenografts.
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| | storage | +4°C | | Background | NSC-697923 is a small-molecule inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13-Uev1A. NSC-697923 blocked formation of Ubc13 and ubiquitin thioester conjugates, and suppressed constitutive NF-κB activity in diffuse large B cell lymphoma cells. Inhibition of ubiquitin-dependent DNA damage signaling was observed, but not formation of the phosphorylated form of histone variant H2AX, which is consistent with NSC-697923 targeting of nuclear Ubc13. Additional data suggested that NSC-697923 interacted with the Ubc13 active site cysteine. UBE2N is an E2 ubiquitin-conjugating enzyme that catalyzes K63-linked poly-Ub chain formation. UBE2N forms a heterodimer with MMS2 or Uev1A to exert its E2 ligase function. NSC-697923 treatment of neuroblastoma cells increased apoptosis and nuclear p53 accumulation, and enhanced tumor suppression. NSC-697923 also inhibited caspase-1 enzymatic activity and NLRP3 protein expression by suppressing the NF-κB signaling pathway. NSC-697923 inhibited joint swelling and NLRP3 inflammasome activation in an animal model of gouty arthritis. | | References | [1] MARY PULVINO. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.[J]. Blood, 2012, 120 8: 1668-1677. DOI:10.1182/blood-2012-02-406074
[2] SAM STRICKSON. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.[J]. Biochemical Journal, 2013, 451 3: 427-437. DOI:10.1042/bj20121651
[3] CURTIS D. HODGE. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting[J]. ACS Chemical Biology, 2015, 10 7: 1718-1728. DOI:10.1021/acschembio.5b00222
[4] J CHENG. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways[J]. Cell Death & Disease, 2014, 5 2: e1079-e1079. DOI:10.1038/cddis.2014.54 |
| | NSC697923 Preparation Products And Raw materials |
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