- Chrysosplenetin
-
- $55.00
-
2026-07-27
- CAS:603-56-5
- Purity: 98.53%
- Supply Ability: 10g
- Chrysosplenetin
-
-
2026-02-02
- CAS:603-56-5
- Min. Order: 5mg
- Purity: 99%
- Supply Ability: 2000tons
- Chrysosplenetin B
-
-
2023-02-24
- CAS:603-56-5
- Min. Order: 5mg
- Purity: ≥90%(HPLC)
- Supply Ability: 10 g
|
| Product Name: | chrysosplenetin B | | Synonyms: | chrysosplenetin B;3,6,7,3'-Tetramethylquercetagetin;5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one;EMD-20940;4H-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-;4H-1-Benzopyran-4-one,5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-;chrgsosplenetin B;5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxychromen-4-one | | CAS: | 603-56-5 | | MF: | C19H18O8 | | MW: | 374.34 | | EINECS: | | | Product Categories: | | | Mol File: | 603-56-5.mol |  |
| | chrysosplenetin B Chemical Properties |
| Melting point | 203-205 °C | | Boiling point | 615.8±55.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble; Methanol: soluble | | form | A crystalline solid | | pka | 6.13±0.40(Predicted) | | color | Light yellow to yellow | | InChI | InChI=1S/C19H18O8/c1-23-11-7-9(5-6-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3 | | InChIKey | NBVTYGIYKCPHQN-UHFFFAOYSA-N | | SMILES | O=C1C(=C(C2C=CC(=C(C=2)OC)O)OC2=CC(=C(C(=C21)O)OC)OC)OC | | LogP | 3.037 (est) |
| | chrysosplenetin B Usage And Synthesis |
| Occurance | Chrysosplenetin B is a tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It derives from a quercetagetin.
Chrysosplenetin B is an O-methylated flavonol. It can be found in the root of Berneuxia thibetica and in Chamomilla recutita.
| | Chemical Properties | Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Laggera pterodonta. | | Uses | Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1]. | | Definition | ChEBI: A tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin. | | IC 50 | CYP3A | | References | [1] Ma L, et al. Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine. Pharm Biol. 2017 Dec;55(1):374-380. DOI:10.1080/13880209.2016.1241810 |
| | chrysosplenetin B Preparation Products And Raw materials |
|