| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
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| | 4-BROMO-3,5-DIMETHYLANISOLE Basic information |
| | 4-BROMO-3,5-DIMETHYLANISOLE Chemical Properties |
| Melting point | 24-25 °C | | Boiling point | 137-139 °C(Press: 20 Torr) | | density | 1.326±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | Appearance | White to light brown <34°C Solid,>36°C Liquid | | InChI | 1S/C9H11BrO/c1-6-4-8(11-3)5-7(2)9(6)10/h4-5H,1-3H3 | | InChIKey | RAWZVIWEDAGMPW-UHFFFAOYSA-N | | SMILES | BrC1=C(C)C=C(OC)C=C1C |
| WGK Germany | WGK 3 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | 4-BROMO-3,5-DIMETHYLANISOLE Usage And Synthesis |
| Synthesis | The reaction was carried out with 4-bromo-3,5-dimethylphenol (25.0 g, 124.3 mmol), iodomethane (35.3 g, 248.6 mmol), and potassium carbonate (34.4 g, 248.6 mmol) in 62.5 mL of DMF with stirring at room temperature for 2 hours. After completion of the reaction, the mixture was diluted with 300 mL of ether and washed sequentially with 250 mL of water and 5 x 100 mL of brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated to give the crude product. Purification by fast column chromatography (silica gel, 90:10 hexane/ethyl acetate) afforded 4-bromo-3,5-dimethylanisole (26 g, 120.8 mmol, 97% yield).1H NMR (CDCl3) δ: 2.39 (s, 6H), 3.76 (s, 3H), 6.67 (s, 2H). | | References | [1] Patent: WO2014/128198, 2014, A1. Location in patent: Page/Page column 44-45
[2] Organic Letters, 2005, vol. 7, # 17, p. 3721 - 3724
[3] Journal of the American Chemical Society, 2007, vol. 129, # 11, p. 3267 - 3286
[4] Angewandte Chemie - International Edition, 2013, vol. 52, # 50, p. 13405 - 13409
[5] Angew. Chem., 2013, vol. 125, # 50, p. 13647 - 13651,5 |
| | 4-BROMO-3,5-DIMETHYLANISOLE Preparation Products And Raw materials |
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