3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]-

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3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- Basic information
Product Name:3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]-
Synonyms:3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]-
CAS:1807873-14-8
MF:C23H26ClF3N2O2
MW:454.91
EINECS:
Product Categories:
Mol File:1807873-14-8.mol
3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- Structure
3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- Chemical Properties
Boiling point 559.9±50.0 °C(predicted)
density 1.311±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka2.70±0.20(predicted)
Safety Information
MSDS Information
3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- Usage And Synthesis
UsesKSI-6666 is an orally active, competitive antagonist for sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 of 6.4 nM. KSI-6666 exhibits anti-inflammatory efficacy in autoimmune encephalomyelitis model and T cell transfer colitis model[1].
IC 50S1PR1: 6.4 nM (IC50)
References[1] Maruyama Y, et al. Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist[J]. bioRxiv, 2023: 2023.05. 08.539826.
3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]- Preparation Products And Raw materials
Tag:3-Azetidinecarboxylic acid, 1-[[5-[1-[[4-chloro-3-(trifluoromethyl)phenyl]ethylamino]ethyl]-2-methylphenyl]methyl]-(1807873-14-8) Related Product Information
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