1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1)

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1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1) Basic information
Product Name:1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1)
Synonyms:1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1);HV1-IN-1 hydrochloride
CAS:1609461-57-5
MF:C19H14F3N5O2.ClH
MW:437.8
EINECS:
Product Categories:
Mol File:1609461-57-5.mol
1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1) Structure
1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1) Chemical Properties
Safety Information
MSDS Information
1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1) Usage And Synthesis
UsesHV1-IN-1 hydrochloride is an inhibitor of the human voltage-gated proton channel (hHV1). HV1-IN-1 hydrochloride works by binding to the VSD of the HV1 channel. The VSD is a component of the HV1 channel that is responsible for detecting changes in membrane potential and triggering the opening of the channel. HV1-IN-1 hydrochloride can be used in the study of cancer, neuroinflammation and immune response[1].
References[1] Piga M, et al. Identification of a Novel Structural Class of HV1 Inhibitors by Structure-Based Virtual Screening[J]. Journal of Chemical Information and Modeling, 2024. DOI:10.1021/acs.jcim.4c00240
1H-Indole-2-carboxamide, N-[3-(2-amino-1H-imidazol-5-yl)phenyl]-5-(trifluoromethoxy)-, hydrochloride (1:1) Preparation Products And Raw materials
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