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| | 8-Quinolinecarbaldehyde Basic information |
| | 8-Quinolinecarbaldehyde Chemical Properties |
| Melting point | 95-96°C | | Boiling point | 314.3±15.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder to crystal | | pka | 3.45±0.17(Predicted) | | color | Light orange to Yellow to Green | | Water Solubility | Insoluble in water. | | Sensitive | Air Sensitive | | BRN | 113039 | | InChI | InChI=1S/C10H7NO/c12-7-9-4-1-3-8-5-2-6-11-10(8)9/h1-7H | | InChIKey | OVZQVGZERAFSPI-UHFFFAOYSA-N | | SMILES | N1C2C(=CC=CC=2C=O)C=CC=1 | | CAS DataBase Reference | 38707-70-9(CAS DataBase Reference) |
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ALFA
| English |
| | 8-Quinolinecarbaldehyde Usage And Synthesis |
| Chemical Properties | Off-white solid | | Uses | Quinoline-8-carboxaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields. | | Synthesis | General method: 8-quinoline methanol was dissolved in anhydrous DMSO (10 v/v), 1 equivalent of polymer bromide was added, and the reaction mixture was stirred at room temperature for the indicated time (see Table 1). Upon completion of the reaction, the mixture was filtered and the polymer bed was washed with DMSO. The DMSO layers were combined and the reaction was quenched with an ice-water mixture and subsequently extracted with ether. The ether layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated to give pure 8-quinolinecarboxaldehyde. All products were structurally confirmed by nuclear magnetic resonance (NMR) and mass spectrometry (MS). | | References | [1] Tetrahedron Letters, 2011, vol. 52, # 51, p. 6971 - 6973
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 10, p. 3480 - 3484
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 31, p. 9084 - 9087
[4] Angew. Chem., 2016, vol. 128, # 31, p. 9230 - 9233,4 |
| | 8-Quinolinecarbaldehyde Preparation Products And Raw materials |
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