Aminopeptidase M manufacturers
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| | Aminopeptidase M Basic information |
| Product Name: | Aminopeptidase M | | Synonyms: | AMINO ACID ARYLAMIDASE;AMINOPEPTIDASE M, 20 UNITS;AMINOPEPTIDASE (MICROSOMAL);AMINOPEPTIDASE M, PORCINE KIDNEY;AMINOPEPTIDASE M TYPE IV-S;AMINOPEPTIDASE M TYPE VI;AMINOPEPTIDASE M TYPE VI-S;ALPHA-AMINOACYL-PEPTIDE HYDROLASE | | CAS: | 9054-63-1 | | MF: | C12H24O2 | | MW: | 0 | | EINECS: | 232-942-5 | | Product Categories: | | | Mol File: | Mol File | ![Aminopeptidase M Structure]() |
| | Aminopeptidase M Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | color | white | | biological source | Porcine kidney | | Water Solubility | physiological buffer: soluble
water: soluble | | Specific Activity | 10-40units/mg protein (Bradford) | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-21 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3 |
| | Aminopeptidase M Usage And Synthesis |
| Chemical Properties | Red lyophilized powder, red-brown liquid or suspension, soluble in water, optimal pH 7.5-9.0.Stability: suspension of cattle containing magnesium sulfate or magnesium chloride as a stabilizer; 4 ℃, pH value of about 8 when stored for 6 months unchanged vitality; lyophilized powder can be stabilized at 4 ℃ for several months. Inhibitors include heavy metal ions, EDTA, citrate; activators include manganese chloride (3-4 mmol/L), Mg2+. Enzyme reaction: aminoacylated peptide + H2O═ amino acid + peptide. | | Uses | Transforming Growth Factor-β1 (TGF-β) human has been used :
- to study the expression of PDGFRB (Platelet derived growth factor receptor β) in association with transforming growth factor-β signaling.
- to stimulate lung fibrosis in human fetal lung fibroblast cell line in order to further measure the in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device.
- to study the effect of TGF-β on HTRA1 (high-temperature requirement A1)-affected Wnt target genes.
| | Uses | Leucine Aminopeptidase, microsomal from porcine kidney has been used in aminopeptidase N (APN) inhibitor screening assay in adenocarcinoma cell line ES-2 and in the inhibition kinetic studies with APN inhibitor. | | General Description | The biologically active form of TGF-β1 (transforming growth factor-β1 human) exists as a disulphide-linked homodimer. In mammals, three isoforms of TGF-β has been identified : TGF-β1, TGF-β2 and TGF-β3. TGF-β1 encodes a 25 kDa peptide. TGF-β1 precursor polypeptide is characterized with hydrophobic signal sequence, pro-region and mature peptide. Cleavage of the precursor at tetrabasic cleavage site results in monomers of carboxy-terminal 112 amino acids. The TGF-β1 gene is mapped to human chromosome 19q13.2. | | Biochem/physiol Actions | TGF-β1 is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2. |
| | Aminopeptidase M Preparation Products And Raw materials |
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