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Alfa Aesar |
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400-6106006 |
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saleschina@alfa-asia.com |
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Energy Chemical |
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| | CBZ-BETA-AMINO-D-ALANINE Basic information | | Synthesis |
| Product Name: | CBZ-BETA-AMINO-D-ALANINE | | Synonyms: | CBZ-BETA-AMINO-D-ALANINE;N-ALPHA-Z-D-2,3-DIAMINOPROPIONIC ACID;N-ALPHA-CARBOBENZOXY-D-ALPHA,BETA-DIAMINOPROPIONIC ACID;N-ALPHA-BENZYLOXYCARBONYL-D-2,3-DIAMINOPROPIONIC ACID;N-CBZ-L-2,3-DIAMINOPROPIONIC ACID;Z-D-2,3-DIAMINOPROPIONIC ACID;Z-D-ALPHA,BETA-DIAMINOPROPIONIC ACID;Z-D-DAP-OH | | CAS: | 62234-37-1 | | MF: | C11H14N2O4 | | MW: | 238.24 | | EINECS: | | | Product Categories: | PROTECTED AMINO ACID & PEPTIDES;chiral | | Mol File: | 62234-37-1.mol |  |
| | CBZ-BETA-AMINO-D-ALANINE Chemical Properties |
| Melting point | ~240 °C (dec.) | | Boiling point | 463.8±45.0 °C(Predicted) | | density | 1.303±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 2.86±0.16(Predicted) | | Appearance | White to off-white Solid | | Optical Rotation | [α]20/D +39.5±1°, c = 1% in 1 M HCl | | BRN | 1993024 | | CAS DataBase Reference | 62234-37-1(CAS DataBase Reference) |
| | CBZ-BETA-AMINO-D-ALANINE Usage And Synthesis |
| Synthesis | CBZ-BETA-AMINO-D-ALANINE has been reported in the literature to be prepared by reacting N-benzyloxycarbonyl-D-asparagine with iodoacetic acid phenyl diacetate. 
At ambient temperature, N-benzyloxycarbonyl-D-asparagine (5.0 g) was added to a stirred solution of iodoacetic acid phenyl diacetate (7.26 g) in a mixture of ethyl acetate (44 ml), acetonitrile (44 ml), and water (22 ml). After stirring for 3 hours, the reaction mixture was cooled to 50°C and then stirred for 2 hours. The insoluble matter was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give N(α)-ZD-2,3-diaminopropionic acid, a white solid, with a yield of 4.15 g. IR (KBr) : 3303.5, 3027.7, 2948.6, 1693.2, 1656.5, 1623.8, 1592.9, 1542.8 cm-1 .1HNMR (D2O-TFA, δ ) : 3.35 (1H, dd, J=13.4 and 8.7Hz), 3.57 (1H, dd, J=13.4 and 5.3Hz), 4.57 (1H, dd, J=8.7 and 5.3Hz), 5.16 (2H, s), 7.43 (5H, s) MASS (m/z) : 239 (M+H)+ mp : 238°C (dec.) [α ]D31 : 8.6° (c=1.0, 1N NaOH aq.) | | Chemical Properties | white to light yellow crystal powde | | Uses | Nalpha-Benzyloxycarbonyl-D-2,3-diaminopropionic Acid |
| | CBZ-BETA-AMINO-D-ALANINE Preparation Products And Raw materials |
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