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| | 2-Butyl-4-chloro-5-formylimidazole Basic information |
| | 2-Butyl-4-chloro-5-formylimidazole Chemical Properties |
| Melting point | 97-100 °C(lit.) | | Boiling point | 384.1±22.0 °C(Predicted) | | density | 1.240 | | vapor pressure | 0.001Pa at 25℃ | | storage temp. | Inert atmosphere,2-8°C | | solubility | soluble in methanol | | pka | 8.87±0.10(Predicted) | | form | Powder to crystal | | color | Pale Yellow to Brown | | Water Solubility | slightly soluble | | InChI | 1S/C8H11ClN2O/c1-2-3-4-7-10-6(5-12)8(9)11-7/h5H,2-4H2,1H3,(H,10,11) | | InChIKey | JLVIHQCWASNXCK-UHFFFAOYSA-N | | SMILES | CCCCc1nc(C=O)c(Cl)[nH]1 | | LogP | 2.5 at 25℃ and pH7.1 | | Surface tension | 58.3mN/m at 1.2g/L and 20℃ | | CAS DataBase Reference | 83857-96-9(CAS DataBase Reference) | | EPA Substance Registry System | 2-Butyl-5-chloroimidazole-4-carbaldehyde (83857-96-9) |
| Hazard Codes | Xi,N | | Risk Statements | 43-51/53 | | Safety Statements | 24-37-61 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | 2 | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Chronic 2
Skin Sens. 1A |
| | 2-Butyl-4-chloro-5-formylimidazole Usage And Synthesis |
| Description | 2-Butyl-4-chloro-5-formylimidazole is an API intermediate used as an intermediate for the anti-hypertensive drug Chlosartan. It can be used in the chemical manufacture of many APIs and advanced intermediates. With the help of this chemical, a number of other chemicals can be manufactured that have further applications in industries such as Losartan manufacturing. | | Chemical Properties | 2-Butyl-4-chloro-5-formylimidazole is Yellow Solid | | Uses | 2-Butyl-4-chloro-5-formylimidazole is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists | | Uses | 2-Butyl-5-chloro-1H-imidazole-4-carboxaldehyde may be used in the preparation of the following symmetrical esters of dialkyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate:
- dimethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diethyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisopropyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- diisobutyl 4-(2-butyl-5-chloro-1H-imidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- di-tert-butyl 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- bis(2-methoxyethyl) 4-(2-butyl-5-chloro-1Himidazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
| | Application | 2-Butyl-4-chloro-1H-imidazole-5-carboxaldehyde (Losartan EP Impurity D) is used for preparation of N-(biphenylylmethyl)imidazoles as angiotensin II antagonists. Losartan USP Related Compound A. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 64, p. 8084, 1999 DOI: 10.1021/jo9824910 | | Synthesis | 2-Butyl-4-chloro-5-formylimidazole was synthesised as follows: Performing condensation reaction of pentamidine hydrochloride with glyoxal and controlling the pH value of the system in the range of 6.0-7.5; after the reaction terminates, arousing dehydration reaction of the compound of formula III, thereby obtaining 2-butyl-1H-imidazole-5(4H)-ketone; and finally, reacting 2-butyl-1H-imidazole-5(4H)-ketone with N,N-dimethylformamide in the presence of phosphorus oxychloride, thereby obtaining 2-butyl-4-chloro-5-formylimidazole. | | storage | 2-Butyl-4-chloro-5-formylimidazole is soluble in DMF, DMSO, Ethanol and Methanol. |
| | 2-Butyl-4-chloro-5-formylimidazole Preparation Products And Raw materials |
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