Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-

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Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Basic information

Product Name:	Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
Synonyms:	Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-;Nucleozin;[4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone;1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine;[4-(2-Chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)methanone;CS-681;Nucleozin >=98% (HPLC), powder;inhibit,Nucleozin,viral,Inhibitor,infection,Influenza Virus,nuclear,nucleoprotein,virus,replication,accumulation
CAS:	341001-38-5
MF:	C21H19ClN4O4
MW:	426.85
EINECS:
Product Categories:
Mol File:	341001-38-5.mol

Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Chemical Properties

density	1.371
storage temp.	2-8°C
solubility	DMSO: >15mg/mL
form	powder
color	yellow
InChI	1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3
InChIKey	OWXBJAPOSQSWAO-UHFFFAOYSA-N
SMILES	Cc1onc(-c2ccccc2)c1C(=O)N3CCN(CC3)c4ccc(cc4Cl)[N+]([O-])=O

Safety Information

MSDS Information

Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Usage And Synthesis

Uses	Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.
Biological Activity	Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.', 'Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.
in vivo	Nucleozin protectes mice challenged with lethal doses of avian influenza A H5N1^[1].
target	Influenza Virus NP

Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Preparation Products And Raw materials

Tag:Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-(341001-38-5) Related Product Information

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