| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
|
| | 13,14-Dihydro-15-keto prostaglandin E1 Basic information |
| Product Name: | 13,14-Dihydro-15-keto prostaglandin E1 | | Synonyms: | 9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID;CDUVSQMTLOYKTR-ZHALLVOQSA-N;13,14-dihydro-15-keto PGE1;9,15-dioxo-11α-hydroxy-prostan-1-oic acid;U 21002;Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-;15-Keto Prostaglandin E0
DISCONTINUED, OFFER K202056;13,14-Dihydro-15-keto prostaglandin E1 | | CAS: | 5094-14-4 | | MF: | C20H34O5 | | MW: | 354.49 | | EINECS: | | | Product Categories: | | | Mol File: | 5094-14-4.mol |  |
| | 13,14-Dihydro-15-keto prostaglandin E1 Chemical Properties |
| Boiling point | 537.2±35.0 °C(Predicted) | | density | 1.072±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly), THF (Slightly) | | form | Oil | | pka | 4.77±0.10(Predicted) | | color | Dark Yellow |
| | 13,14-Dihydro-15-keto prostaglandin E1 Usage And Synthesis |
| Description | 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM. | | Uses | 15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders. | | Definition | ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-). | | References | [1] R. KATZENSCHLAGER . Synergism between PGE1-metabolites (13,14-dihydro-prostaglandin E1, 15-keto prostaglandin E1, 15-keto-13,14-dihydro-prostaglandin E1) and nitric oxide (NO) on platelet aggregation[J]. Prostaglandins, leukotrienes, and essential fatty acids, 1992, 45 3: Pages 207-210. DOI: 10.1016/0952-3278(92)90114-x |
| | 13,14-Dihydro-15-keto prostaglandin E1 Preparation Products And Raw materials |
|