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| | 11-DEOXY PROSTAGLANDIN E1 Basic information |
| Product Name: | 11-DEOXY PROSTAGLANDIN E1 | | Synonyms: | 11-DEOXY PROSTAGLANDIN E1;9-OXO-15S-HYDROXY-PROST-13E-EN-1-OIC ACID;7-((1R,2R)-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid;11-deoxy Prostaglandin E1 Exclusive;Prost-13-en-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)- | | CAS: | 37786-00-8 | | MF: | C20H34O4 | | MW: | 338.48 | | EINECS: | | | Product Categories: | | | Mol File: | 37786-00-8.mol |  |
| | 11-DEOXY PROSTAGLANDIN E1 Chemical Properties |
| Boiling point | 509.7±35.0 °C(Predicted) | | density | 1.070±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1) | | form | A crystalline solid | | pka | 4.77±0.10(Predicted) |
| | 11-DEOXY PROSTAGLANDIN E1 Usage And Synthesis |
| Uses | 11-Deoxy prostaglandin E1 (AY-23578; Doproston B) is an analog of prostaglandin E1 (PGE1) with bronchodilator activity. 11-Deoxy prostaglandin E1 inhibits histamine-induced bronchoconstriction and causes relaxation of tracheal strips in isolated guinea pigs[1]. | | Definition | ChEBI: 11-deoxyprostaglandin E1 is a prostanoid. | | in vivo | 11-Deoxy prostaglandin E1 (administered as a spray) has no significant bronchodilator effect in guinea pigs and cats[1].
| | References | [1] Greenberg R, et al. The bronchodilator acitivity of an 11-deoxyprostaglandin (AY 23 578). Can J Physiol Pharmacol. 1975 Oct;53(5):799-809. DOI:10.1139/y75-110 |
| | 11-DEOXY PROSTAGLANDIN E1 Preparation Products And Raw materials |
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