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(R)-1-Boc-3-methylpiperazine

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Company Name: Shanghai Boc Chemical Co., Ltd.
Tel: 021-34975602; +8618721111801
Email: shangli@bocchem.com
Products Intro: Product Name:(R)-1-Boc-3-methyl-piperazine
CAS:163765-44-4
Purity:0.99 Package:1000KG；100KG;10KG
Company Name: Shanghai UCHEM Inc.
Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Products Intro: Product Name:(R)-4-Boc-2-methylpiperazine
CAS:163765-44-4
Purity:0.99 Package:10g;37USD|100g;211USD|500g;788USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-（0）57185586718; +8613336195806
Email: sales@capot.com
Products Intro: Product Name:(R)-4-Boc-2-methylpiperazine
CAS:163765-44-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Chembon Pharmaceutical Co., Ltd.
Tel: +86-28-8425-2981
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Products Intro: Product Name:(R)-4-Boc-2-Methylpiperazine
CAS:163765-44-4
Purity:>98% Package:25g,100g,250g,1kg,10kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:(R)-tert-butyl 3-methylpiperazine-1-carboxylate
CAS:163765-44-4
Purity:98% HPLC Package:5G,10G,25G,50G,100G,250G,1KG

(R)-1-Boc-3-methylpiperazine manufacturers
(R)-1-Boc-3-methylpiperazine Basic information
Product Name:(R)-1-Boc-3-methylpiperazine
Synonyms:(R)-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-N-BOC-2-METHYLPIPERAZINE;(R)-N4-BOC-2-METHYLPIPERAZINE;TERT-BUTYL (R)-3-METHYL-1-PIPERAZINECARBOXYLATE;(R)-4-N-BOC-2-METHYLPIPERAZINE;(R)-3-METHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-1-BOC-3-METHYLPIPERAZINE;(R)-1-TERT-BUTOXYCARBONYL-3-METHYLPIPERAZINE
CAS:163765-44-4
MF:C10H20N2O2
MW:200.28
EINECS:
Product Categories:Piperazines;Piperaizine;Piperazine series;pharmacetical
Mol File:163765-44-4.mol
(R)-1-Boc-3-methylpiperazine Structure
(R)-1-Boc-3-methylpiperazine Chemical Properties
Melting point 40-45 °C
Boiling point 268.7±15.0 °C(Predicted)
density 0.997±0.06 g/cm3(Predicted)
Fp 223 °F
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka8.52±0.40(Predicted)
form Crystalline Powder
color White
Optical Rotation[α]/D +16±2°, c = 1 in dioxane
InChIInChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m1/s1
InChIKeyFMLPQHJYUZTHQS-MRVPVSSYSA-N
SMILESN1(C(OC(C)(C)C)=O)CCN[C@H](C)C1
CAS DataBase Reference163765-44-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41-36/37/38
Safety Statements 26-39-37/39
WGK Germany 3
F 10-34
HS Code 29335990
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(R)-1-Boc-3-methylpiperazine Usage And Synthesis
Chemical PropertiesWhite solid
Uses(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid. (R)-4-Boc-2-methylpiperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
SynthesisTo a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).

(R)-4-Boc-2-methylpiperazine
References[1] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 191
[2] Patent: US2010/216812, 2010, A1. Location in patent: Page/Page column 45
[3] Patent: US2011/201622, 2011, A1. Location in patent: Page/Page column 14
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 11, p. 3282 - 3285
[5] Patent: US2005/70549, 2005, A1
(R)-1-Boc-3-methylpiperazine Preparation Products And Raw materials
Raw materials(R)-(-)-2-Methylpiperazine-->Di-tert-butyl dicarbonate-->2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
Preparation Products(R)-1,2-DIMETHYL-PIPERAZINE
Tag:(R)-1-Boc-3-methylpiperazine(163765-44-4) Related Product Information
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