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| | GLYCOPROTEIN, ALPHA1-ACID HUMAN Basic information |
| Product Name: | GLYCOPROTEIN, ALPHA1-ACID HUMAN | | Synonyms: | AGP;ALPHA1-ACID GLYCOPROTEIN;ALPHA1-ACID GLYCOPROTEIN, HUMAN;ALPHA1-ACID GLYCOPROTEIN, HUMAN SERUM;ALPHA1-ACID GLYCOPROTEIN (OROSOMUCOID);ALPHA-1 ACID GLYCOPROTEIN PLASMA;ALPHA1-AG, HUMAN;ALPHA-1-SEROMUCOID, HUMAN | | CAS: | 66455-27-4 | | MF: | NULL | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GLYCOPROTEIN, ALPHA1-ACID HUMAN Structure]() |
| | GLYCOPROTEIN, ALPHA1-ACID HUMAN Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: 10 mg/mL, clear, colorless | | form | Lyophilized | | biological source | human plasma | | Merck | 13,8018 | | Specific Activity | 88-120nmol/min·mg |
| Hazard Codes | B | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 10-21 | | Storage Class | 11 - Combustible Solids |
| | GLYCOPROTEIN, ALPHA1-ACID HUMAN Usage And Synthesis |
| Chemical Properties | This product is brown or brownish powder, slightly peculiar odor, tasteless. Melting point 120℃. Soluble in water, almost insoluble in methanol, chloroform, benzene, cyclohexane and so on. This product is a kind of proteoglycan, protein content 25%-30%. It has anti-tumor activity both in vivo and in vitro. Its anti-tumor effect is related to its excitation of the body's anti-tumor immune function. Yunzhi polysaccharide can enhance the cellular immune function, and promote the delayed allergic reaction and lymphocyte proliferation reaction. It can also increase the production of interferon, interleukins 1 and 2 and prostaglandins. It can also normalize the low IgG and IgM of the tumor-bearing animals. In addition, it could not enhance the phagocytosis of macrophages in tumor-bearing animals. After oral administration, Yunzhi polysaccharide is absorbed from the digestive tract and distributed to organs and tumor tissues throughout the body, and about 70% of it is eliminated from the body within 24 h. It is mainly excreted in the form of carbon dioxide through the respiratory tract. | | Uses | α1-Acid glycoprotein from human plasma has been used:
- as negatively charged protein to investigate the adsorption processes onto the surface of polyelectrolyte multilayers
- to incubate plates coated with purified antiserum in the study to investigate its serum concentration by ELISA
- to study the effect of its different concentrations on the antiviral activity of human immunodeficiency virus (HIV) protease inhibitors
| | Uses | GLYCOPROTEIN, ALPHA1-ACID HUMAN was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine. | | General Description | α-1-Acid glycoprotein (AGP)/orosomucoid (ORM), a glycoprotein has a molecular weight of 41-43kDa. It is considered as one of the important acute phase proteins in humans and rats. AGP may belong to the lipocalin family. | | Biochem/physiol Actions | α1-Acid glycoprotein possesses immunomodulating effects. It has the ability to bind to acidic drugs, like phenobarbital. | | Purification Methods | Purify the glycoprotein 1 acid by passage through a carboxymethyl cellulose column, then through a Sephadex G-25 column. [Aronson et al. J Biol Chem 243 4564 1968.] |
| | GLYCOPROTEIN, ALPHA1-ACID HUMAN Preparation Products And Raw materials |
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