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| | cis-Octahydro-1H-isoindole hydrochloride Basic information |
| Product Name: | cis-Octahydro-1H-isoindole hydrochloride | | Synonyms: | CIS-HEXAHYDROISOINDOLINE HYDROGEN CHLORIDE;(3aR,7aS)-rel-Octahydro-1H-isoindole hydrochloride;(3aR,7aS)-rel-octahydro-1H-Isoindole, hydrochloride (1:1);1H-Isoindole,octahydro-, hydrochloride, (3aR,7aS)-rel- (9CI);cis-Octahydroisoindole hydrochloride;Cis-hexahydroisoindolineHCL;5-[2-(4-{[(1S)-4-ethoxy-1-(ethoxycarbonyl)-4-oxobutyl]carbamoyl}phenyl)ethyl]-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-aminium;(3aR,7aS)-octahydro-1H-isoindole hydrochloride | | CAS: | 161829-92-1 | | MF: | C8H16ClN | | MW: | 161.67234 | | EINECS: | 1806241-263-5 | | Product Categories: | | | Mol File: | 161829-92-1.mol |  |
| | cis-Octahydro-1H-isoindole hydrochloride Chemical Properties |
| Melting point | 121-123 °C | | storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid | | InChI | InChI=1/C8H15N.ClH/c1-2-4-8-6-9-5-7(8)3-1;/h7-9H,1-6H2;1H/t7-,8+; | | InChIKey | CLQIZUYXKFTUEB-KVZVIFLMNA-N | | SMILES | [H][C@]12CCCC[C@@]1([H])CNC2.Cl |&1:1,6,r| |
| | cis-Octahydro-1H-isoindole hydrochloride Usage And Synthesis |
| Description | Cis-Octahydro-1H-isoindole hydrochloride is an important intermediate in the synthesis of mitiglinide which is a new oral hypoglycemic drug for the treatment of type II diabetes for the first marked in Japan | | Preparation | Phthalimide was used as raw material to react with KOH. Benzyl bromide was subsequently added to the solution to obtain the N-benzylphthalimide. The addition of lithium tetrahydroaluminum, reducing compound N-benzylphthalimide, yields N-benzyldihydroisoindole. Finally, cis-Octahydro-1H-isoindole hydrochlorid is obtained by Pd/C catalysis and reduction |
| | cis-Octahydro-1H-isoindole hydrochloride Preparation Products And Raw materials |
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