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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid

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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid manufacturers

  • Zaltoprofen
  • Zaltoprofen pictures
  • $34.00
  • 2026-08-08
  • CAS:74711-43-6
  • Purity: 99.72%
  • Supply Ability: 10g
  • Zaltoprofen
  • Zaltoprofen pictures
  • 2025-12-25
  • CAS:74711-43-6
  • Min. Order: 1gram
  • Purity: 99%
  • Supply Ability: 10kg
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Basic information
Product Name:10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
Synonyms:2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid;Zaltoprofen/ 10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid;Salafapinon;Soleton;Dibenzo(B,F)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-;Einecs 277-973-5;Zaltoprofen (unspecified);CAS No:74711-43-6 Dibenzo[b,f]thiepin-2-aceticacid, 10,11-dihydro-a-Methyl-10-oxo-
CAS:74711-43-6
MF:C17H14O3S
MW:298.36
EINECS:277-973-5
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Zaltoprofen
Mol File:74711-43-6.mol
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Structure
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Chemical Properties
Melting point 129-1310C
Boiling point 500.5±50.0 °C(Predicted)
density 1.329±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka4.21±0.10(Predicted)
color Off-White to Pale Yellow
Merck 14,10112
InChIInChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)
InChIKeyMUXFZBHBYYYLTH-UHFFFAOYSA-N
SMILESC(C1=CC=C2SC3=CC=CC=C3C(CC2=C1)=O)(C)C(=O)O
Safety Information
RTECS HQ2526700
HS Code 2934.99.4400
MSDS Information
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Usage And Synthesis
Chemical PropertiesOff-White to Pale Yellow Solid
UsesZaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.
UsesAnti-inflammatory activity resides in (S)-enantiomer.
DefinitionChEBI: Zaltoprofen is an organic molecular entity.
in vivo

Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats[2].
Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner[2].

Animal Model:Eight-week-old male Wistar rats were injected Bradykinin every 15 min[2]
Dosage:5, 10, 20 mg/kg
Administration:A single p.o.
Result:Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.
The duration of analgesic effect was 60-90 min.
IC 50COX-2: 0.34 μM (IC50); COX-1: 1.3 μM (IC50)
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Preparation Products And Raw materials
Tag:10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid(74711-43-6) Related Product Information
Zaltoprofen Benztropine mesylate Pivalic acid Methyl salicylate Methyl 2,2-dimethylphenylacetate Tribenuron methyl Ethyl 2-(Chlorosulfonyl)acetate 4-Methylphenylacetic acid Dihydromyrcenol Methanol Methyl acrylate Dimethylbenzylcarbinyl acetate Ibuprofen Methylparaben Zalcitabine Zafirlukast ZANAMIVIR HYDRATE N-Ethyl-N-3-((3-dimethylamino-1-oxo-2-propenyl)phenyl)acetamide