1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA manufacturers
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| | 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Basic information |
| Product Name: | 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA | | Synonyms: | 1-PHENYL-3-(THIAZOL-2-YL)THIOUREA;1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA;:1-phenyl-3-(1,3-thiazol-2-yl)thiourea;1-phenyl-3-(2-thiazolyl)-2-thio-ure;n-phenyl-n’-2-thiazolyl-thioure;phenylthiazolylthiourea;Urea, 1-phenyl-3-(2-thiazolyl)-2-thio.;1-Phenyl-3-(2-thiazolyl)thiourea | | CAS: | 14901-16-7 | | MF: | C10H9N3S2 | | MW: | 235.33 | | EINECS: | 238-970-4 | | Product Categories: | | | Mol File: | 14901-16-7.mol |  |
| | 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Chemical Properties |
| Melting point | 183-185 °C (dec.)(lit.) | | density | 1.3479 (rough estimate) | | refractive index | 1.5500 (estimate) | | form | Solid | | color | Off-white to yellow | | CAS DataBase Reference | 14901-16-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | RTECS | YU1398000 |
| | 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Usage And Synthesis |
| Chemical Properties | light brown fine crystalline powder | | Uses | U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2]. | | in vivo | U-14624 (50 mg/kg; i.p.; daily for 5-7 days) suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes in rats[2]. | Animal Model: | 150-260 g, Male Sprague-Dawley rats[2] | | Dosage: | 25 mg/kg | | Administration: | I.p.; daily for 3 days | | Result: | Prolonged the time required for clearance of pentobarbital from both the plasma and brain, slept significantly longer. |
| Animal Model: | 150-260 g, Male Sprague-Dawley rats[2] | | Dosage: | 50 mg/kg | | Administration: | I.p.; daily for 5-7 days | | Result: | Suppressed the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes. |
| | References | [1] Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. DOI:10.3181/00379727-133-34571
[2] Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. DOI:10.1016/0006-2952(80)90345-7 |
| | 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA Preparation Products And Raw materials |
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