(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide

(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide Suppliers list

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(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide Basic information

Product Name:	(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide
Synonyms:	(R)-(+)-AtenololHCl;4-[(R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide;2-[4-[(2R)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide;2-[4-[(2R)-2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethanamide;(R)-(+)-Atenolol,(+)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide;R(+)-ATENOLOL LESS ACTIVE ENANTIOME;Benzeneacetamide, 4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-
CAS:	56715-13-0
MF:	C14H22N2O3
MW:	266.34
EINECS:
Product Categories:	Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	56715-13-0.mol

(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide Chemical Properties

Melting point	148-152 °C(lit.)
Boiling point	508.0±50.0 °C(Predicted)
density	1.125±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL
pka	13.88±0.20(Predicted)
form	solid
color	pale yellow
Optical Rotation	[α]25/D +16°, c = 1 in 1 M HCl
InChI	InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)/t12-/m1/s1
InChIKey	METKIMKYRPQLGS-GFCCVEGCSA-N
SMILES	C1(CC(N)=O)=CC=C(OC[C@H](O)CNC(C)C)C=C1

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS Information

Provider	Language
SigmaAldrich	English

(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide Usage And Synthesis

Description	(+)-Atenolol is an enantiomer of the β₁-adrenergic receptor (β₁-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (K_i = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.
Uses	Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).
Uses	Antihypertensor
Uses	less active enantiomer
Definition	ChEBI: The (R)-enantiomer of atenolol.
IC 50	β adrenergic receptor
references	[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.

(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide Preparation Products And Raw materials

Raw materials

Tag:(+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide(56715-13-0) Related Product Information

4-Methoxyphenylacetamide S(-)-ATENOLOL 4-Hydroxyphenylacetamide Atenolol (+)-4-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]benzeneacetamide CHEMBRDG-BB 9070877 3-(Isopropylamino)-1,2-propanediol 1-Methylamino-3-phenoxy-propan-2-ol 1-Amino-3-phenoxy-propan-2-ol (R)-3-Isopropylamino-1,2-propanediol (2R)-(+)-1-Amino-3-phenoxy-2-propanol 1-Amino-3-(4-ethylphenoxy)propan-2-ol CHEMBRDG-BB 5482082 AKOS BC-1949 4-(3-Amino-2-hydroxypropoxy)phenylacetamide 3-(4-methylphenoxy)propan-1-amine ATENOLOL IMPURITY STANDARD

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