4-(Dimethylamino)benzamide manufacturers
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| | 4-(Dimethylamino)benzamide Basic information |
| | 4-(Dimethylamino)benzamide Chemical Properties |
| Melting point | 203.5 °C | | Boiling point | 325.5±25.0 °C(Predicted) | | density | 1.123±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 16.89±0.50(Predicted) | | Appearance | White to off-white Solid |
| | 4-(Dimethylamino)benzamide Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 4-(dimethylamino)benzamide from p-dimethylaminobenzaldehyde: In a 10 mL pressurized vial, Sc(OTf)3 (10 mol%, 49 mg), p-dimethylaminobenzaldehyde (1 mmol), NH2OH-HCl (1 mmol, 69 mg), and Na2CO3 (1 mmol) were added, followed by H2O (1 mL). The vials were sealed using snap-on lids and placed in a single-mode CEM Discover Bench Mate microwave reactor and irradiated at 300 W power and 135 °C for 15-35 min. The progress of the reaction was monitored by TLC during the reaction. Upon completion of the reaction, the mixture was cooled to room temperature and extracted with EtOAc (3 × 10 mL). The organic phases were combined, dried with Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using EtOAc/hexane (3:7) as eluent and the final product was characterized by physical properties and spectral data. | | References | [1] Journal of Materials Chemistry, 2012, vol. 22, # 35, p. 18115 - 18118
[2] European Journal of Organic Chemistry, 2011, # 12, p. 2226 - 2229
[3] Tetrahedron Letters, 2011, vol. 52, # 44, p. 5851 - 5854
[4] Catalysis Communications, 2017, vol. 91, p. 38 - 42
[5] Organic Letters, 2016, vol. 18, # 22, p. 5788 - 5791 |
| | 4-(Dimethylamino)benzamide Preparation Products And Raw materials |
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