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| | Scandium trifluoromethanesulfonate Basic information |
| Product Name: | Scandium trifluoromethanesulfonate | | Synonyms: | SCANDIUM TRIFLUOROMETHANESULFONATE;SCANDIUM TRIFLUOROMETHANESULFONATE, POLYMER-BOUND;SCANDIUM(III) TRIFLUOROMETHANESULPHONATE;PS-Sc(OTf)2, Scandium triflate resin;Scandium(III) bis(trifluoromethanesulfonate), polymer-bound;Scandium(III) trifluoromethanesulfonate, (Scandium triflate),min. 97%;Scandium(III) trifluoromethanesulfonate,95%;scandium(iii) | | CAS: | 144026-79-9 | | MF: | C3F9O9S3Sc | | MW: | 492.16 | | EINECS: | | | Product Categories: | metal triflate compounds;trifluoromethanesulfonate,OTf;triflate;Boron, Nitrile, Thio,& TM-Cpds;OTf&NTf series;Other Metal;Catalysts for Organic Synthesis;Classes of Metal Compounds;Homogeneous Catalysts;Metal Triflates;Sc (Scandium) Compounds;Stable Lewis Acids in Aqueous Media;Synthetic Organic Chemistry;Transition Metal Compounds | | Mol File: | 144026-79-9.mol |  |
| | Scandium trifluoromethanesulfonate Chemical Properties |
| Melting point | >300 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Water (Slightly) | | form | Powder | | color | White | | Water Solubility | Soluble in water, alcohol and acetonitrile. | | Sensitive | Hygroscopic | | Hydrolytic Sensitivity | 6: forms irreversible hydrate | | BRN | 8510151 | | Stability: | hygroscopic | | InChI | InChI=1S/3CHF3O3S.Sc/c3*2-1(3,4)8(5,6)7;/h3*(H,5,6,7);/q;;;+3/p-3 | | InChIKey | HZXJVDYQRYYYOR-UHFFFAOYSA-K | | SMILES | C(F)(S([O-])(=O)=O)(F)F.C(F)(F)(F)S([O-])(=O)=O.C(F)(F)(F)S([O-])(=O)=O.[Sc+3] | | CAS DataBase Reference | 144026-79-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 3-10 | | Hazard Note | Irritant | | TSCA | No | | HS Code | 28469099 | | Storage Class | 11 - Combustible Solids |
| | Scandium trifluoromethanesulfonate Usage And Synthesis |
| Description | Scandium trifluoromethanesulfonate, commonly called Scandium(III) triflate, is a chemical compound with formula Sc(SO3CF3)3, a salt consisting of scandium cations Sc3+ and triflate SO3CF3 anions.
Scandium(III) triflate is an extremely active, efficient, recoverable and reusable acylation catalyst. Its an important catalyst for the Friedel-Crafts acylation, Diels-Alder reactions and other carbon-carbon bond-forming reactions. It also stereochemically catalyzes the radical polymerization of acrylates. Scandium(III) triflate complex of (4′S,5′S)-2,6-bis[4′-(triisopropylsilyl)oxymethyl-5′-phenyl-1′,3′-oxazolin-2′-yl]pyridine has been employed as catalyst for the asymmetric Friedel-Crafts reaction between substituted indoles and methyl (E)-2-oxo-4-aryl-3-butenoates. | | Chemical Properties | White powder | | Uses | Scandium(III) trifluoromethanesulfonate is widely used as a catalyst in hydrothiolation, selective two-electron reduction of oxygen by ferrocene derivatives and vinylogous Fridel-crafts alkylation of indoles and pyrrole in water. It is involved in the Mukaiyama aldol addition and stereochemically catalyzes the radical polymerization of acrylates. It acts as a Lewis acid catalyst and used in the synthesis of bullvalone via a stabilized sulfur ylide. | | Uses | Scandium Triflate is an important catalyst used in Friedel-Crafts acylation, Baylis-Hillman reaction and other carbon-carbon bond forming reactions. | | Preparation | Scandium triflate (Scandium trifluoromethanesulfonate) can be prepared from the corresponding oxide (Sc2O3) and aqueous trifluoromethanesulfonic acid (TfOH). After filtration and concentration of the clear aqueous solution in vacuo, the resulting hydrated salt is dried in vacuo (<1 mmHg) at 200°C for 40 h to afford the anhydrous triflate stored over P2O5.
| | Application | Scandium(III) triflate was used as a catalyst in:
Hydrothiolation reaction of aromatic and aliphatic thiols.
Selective two-electron reduction of O2 by ferrocene derivatives.
Vinylogous Friedel-Crafts alkylation of indoles and pyrroles in water.
Synthesis of β-cyanoketones.
Combination with triethylsilane to reductively open functionalized pyranoside rings.
The key steps of synthesis of bullvalone via a stabilized sulfur ylide. | | Reactions |
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Water tolerant Lewis acid.
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Commonly used in a range of Lewis acid catalyzed reactions.
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Efficient metal source for Lewis acid catalyzed asymmetric reactions.
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Catalyzes Friedel-Crafts alkylation, acylation and related reactions.
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Catalyzes various domino- and multi-component processes.
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Catalyzes electrophilic additions of alpha-diazoesters with ketones.
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Catalyzes carbon insertion reactions.
 | | General Description | Scandium(III) triflate is an extremely active, efficient, recoverable and reusable acylation catalyst. Its an important catalyst for the Friedel-Crafts acylation, Diels-Alder reactions and other carbon-carbon bond-forming reactions. It also stereochemically catalyzes the radical polymerization of acrylates. Scandium(III) triflate complex of (4′S,5′S)-2,6-bis[4′-(triisopropylsilyl)oxymethyl-5′-phenyl-1′,3′-oxazolin-2′-yl]pyridine has been employed as catalyst for the asymmetric Friedel-Crafts reaction between substituted indoles and methyl (E)-2-oxo-4-aryl-3-butenoates. | | reaction suitability | core: scandium
reagent type: catalyst |
| | Scandium trifluoromethanesulfonate Preparation Products And Raw materials |
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