N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea

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N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea manufacturers

  • VULM 1457
  • VULM 1457 pictures
  • $41.00
  • 2026-05-11
  • CAS:228544-65-8
  • Purity: 99.92%
  • Supply Ability: 10g
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Basic information
Product Name:N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea
Synonyms:VULM 1457;VULM 1457,acyl-CoA:cholesterol acyltransferase,hypercholesterolaemia,Diacylglycerol acyltransferase,ischaemia-reperfusion,myocardial,Diglyceride acyltransferase,mono- acylglycerol acyltransferase,Inhibitor,VULM1457,acyl-CoA,cholesterol acyltransferase,Acyltransferase,hypolipidaemic,inhibit,VULM-1457,diabetes mellitus;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]-;1-(2,6-Diisopropylphenyl)-3-(4-((4-nitrophenyl)thio)phenyl)urea;N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea
CAS:228544-65-8
MF:C25H27N3O3S
MW:449.57
EINECS:
Product Categories:
Mol File:228544-65-8.mol
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Structure
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Chemical Properties
Boiling point 535.0±50.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 100 mM in DMSO
form Powder
pka13.79±0.70(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Usage And Synthesis
UsesVULM 1457 is a cholesterol acyltransferase inhibitor.
Biological ActivityAcyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. Decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolaemic rats.
in vivo

VULM 1457 significantly reduces atherogenic activity in animal experimental atherosclerosis[1].
VULM 1457 protect the hearts of diabetic–hypercholesterolaemic rats against ischaemia/reperfusion injury in vivo[2].
VULM 1457 (50 mg/kg/day; administered as an admixture to the fat-cholesterol diet for 5 days) significantly decreases plasma total cholesterol levels (1.7±0.1 mM vs. 2.9±0.5 mM in diabetic–hypercholesterolaemic animals). The hypolipidaemic effect of VULM 1457 is also observed in the liver of DM-HCH rats (3.9±0.2 mg/g vs. 7.4±1.0 mg/g)[2].

Animal Model:Male Wistar rats (250-300 g body weight), fed a standard diet and tap water ad libitum[2]
Dosage:50 mg/kg/day
Administration:Administered as an admixture to the fat-cholesterol diet for 5 days
Result:Improved the overall myocardial ischaemia-reperfusion injury outcomes in the diabetic-hypercholesterolaemic rats by suppressing arrhythmogenesis as well as by reducing myocardial necrosis, aside from remarkable hypolipidaemic activity.
IC 50ACAT
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea Preparation Products And Raw materials
Tag:N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea(228544-65-8) Related Product Information
N-[2,6-Bis(1-methylethyl)phenyl]-N'-[4-[(4-nitrophenyl)thio]phenyl]urea 4-Amino-4'-nitrodiphenyl sulfide 4-Hydroxy-L-phenylglycine N-(Cyanomethyl)-N-tetradecyl-2-propenamide 2-Furoic acid [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate