| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
|
| | Ethyl 6-chloro-2-pyridinecarboxylate Basic information |
| Product Name: | Ethyl 6-chloro-2-pyridinecarboxylate | | Synonyms: | 6-Chloropyridine-2-carboxylic acid ethyl ester;2-Pyridinecarboxylic acid, 6-chloro-, ethyl ester;2-Pyridinecarboxylic acid, 6-chloro-, ethyl ester (9CI, ACI);6-chloro-2-Pyridinecarboxylic acid ethyl ester (9CI ACI);6-Chloropyridin-2-carboxylic acid ethyl ester;6-chloro-2-Pyridinecarboxylic acid ethyl ester;ethyl 6-chloropyridine-2-carboxylate | | CAS: | 21190-89-6 | | MF: | C8H8ClNO2 | | MW: | 185.61 | | EINECS: | | | Product Categories: | | | Mol File: | 21190-89-6.mol |  |
| | Ethyl 6-chloro-2-pyridinecarboxylate Chemical Properties |
| Boiling point | 289℃ | | density | 1.245 | | Fp | 129℃ | | storage temp. | Store at room temperature | | form | Crystalline | | pka | -0.89±0.10(Predicted) | | color | Pale yellow |
| | Ethyl 6-chloro-2-pyridinecarboxylate Usage And Synthesis |
| Synthesis | Step D: Preparation of ethyl 6-chloro-2-pyridinecarboxylate: 6-chloro-2-pyridinecarboxylic acid (23.5 g, 149 mmol), anhydrous ethanol (100 mL), and toluene (400 mL) were added to a round-bottomed flask equipped with a condenser. Concentrated sulfuric acid (4 mL) was slowly added to the reaction system, followed by heating the mixture to reflux and maintaining the reaction for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by distillation under reduced pressure and the resulting oily product was dissolved in ethyl acetate (200 mL), washed with 10% aqueous potassium carbonate and dried over anhydrous sodium sulfate. Finally, the dried organic phase was concentrated under reduced pressure to afford ethyl 6-chloro-2-pyridinecarboxylate (26 g, 94% yield). | | References | [1] Patent: WO2012/82689, 2012, A1. Location in patent: Page/Page column 56
[2] European Journal of Organic Chemistry, 2014, vol. 2014, # 28, p. 6295 - 6302
[3] Organic Letters, 2014, vol. 16, # 15, p. 3860 - 3863 |
| | Ethyl 6-chloro-2-pyridinecarboxylate Preparation Products And Raw materials |
|