| Company Name: |
Cool Pharm, Ltd |
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021-60455363 18019463053 |
| Email: |
sales@coolpharm.com |
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| | 7-Bromo-2-methoxyquinoline Basic information |
| | 7-Bromo-2-methoxyquinoline Chemical Properties |
| Melting point | 68 °C | | Boiling point | 312.6±22.0 °C(Predicted) | | density | 1.516±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 1.62±0.50(Predicted) | | Appearance | White to light brown Solid |
| | 7-Bromo-2-methoxyquinoline Usage And Synthesis |
| Synthesis | 7-Bromo-2-chloroquinoline (2) was used as starting material and reacted with sodium methanol to prepare 7-bromo-2-methoxyquinoline (1) in 98% yield. The melting point of the product was 68-69 °C. The nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) data were as follows: δ 8.05 (d, 1H, J = 1.8 Hz), 7.93 (d, 1H, J = 8.7 Hz), 7.57 (d, 1H, J = 9.0 Hz), 7.47 (dd, 1H, J = 8.7 Hz, 1.8 Hz), 6.91 (d, 1H, J = 9.0 Hz), 4.00 (s, 3H). The mass spectrum (MS, APCI, pos. 30V) showed a molecular ion peak m/z of 239.06 ([M + H]+). | | References | [1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 4, p. 1657 - 1662
[2] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 621 - 631
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 10, p. 2048 - 2056 |
| | 7-Bromo-2-methoxyquinoline Preparation Products And Raw materials |
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