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4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one

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4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Suppliers list
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Products Intro: Product Name:4-(4-fluorophenyl)-7-(((5-((1s)-1-hydroxy-1-(trifluoromethyl)propyl)-1,3,4-oxadiazol-2-yl)amino)methyl)-2h-1-benzopyran-2-one
CAS:910656-27-8
Purity:0.99 Package:1kg
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Products Intro: Product Name:Setileuton
CAS:910656-27-8
Purity:99.31% Package:1mg;197USD|5mg;479USD|10mg;653USD
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
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Products Intro: Product Name:MK-0633
CAS:910656-27-8
Purity:NLT 98% Remarks:MC579265
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Setileuton；MK 0633;MK-0633;MK0633
CAS:910656-27-8
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: CAS:910656-27-8

4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one manufacturers

  • Setileuton
  • Setileuton pictures
  • $197.00
  • 2026-05-11
  • CAS:910656-27-8
  • Purity: 99.31%
  • Supply Ability: 10g
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Basic information
Product Name:4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one
Synonyms:MK-0633;4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one;4-(4-fluorophenyl)-7-[[[5-[(2S)-1,1,1-trifluoro-2-hydroxybutan-2-yl]-1,3,4-oxadiazol-2-yl]amino]methyl]chromen-2-one;2H-1-Benzopyran-2-one, 4-(4-fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-;Setileuton, 10 mM in DMSO;Setileuton
CAS:910656-27-8
MF:C22H17F4N3O4
MW:463.38
EINECS:
Product Categories:
Mol File:910656-27-8.mol
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Structure
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Chemical Properties
Melting point 92.9-94.3 °C
Boiling point 609.6±65.0 °C(Predicted)
density 1.478
pka9.65±0.29(Predicted)
Safety Information
MSDS Information
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Usage And Synthesis
UsesSetileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1].
in vivo

Setileuton (5 mg/kg, i.v.; or 20 mg/kg, p.o., single dose) exhibits good pharmacokinetic profils with a half-time T1/2 of 3.3 h, and a bioavailability of 66% in rat model[1].

References[1] Ducharme Y, et al., The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor. ACS Med Chem Lett. 2010 Apr 13;1(4):170-4. DOI:10.1021/ml100029k
4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Preparation Products And Raw materials
Tag:4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one(910656-27-8) Related Product Information
Setileuton tosylate 4-(4-Fluorophenyl)-7-[[[5-[(1S)-1-hydroxy-1-(trifluoromethyl)propyl]-1,3,4-oxadiazol-2-yl]amino]methyl]-2H-1-benzopyran-2-one Uniprofen chebulagic acid Indirubin-3'-oxime Zileuton