Propenyl-L-NIO (hydrochloride)

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Propenyl-L-NIO (hydrochloride) Suppliers list
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Propenyl-L-NIO (hydrochloride) Basic information
Product Name:Propenyl-L-NIO (hydrochloride)
Synonyms:Propenyl-L-NIO (hydrochloride)
CAS:
MF:C10H20ClN3O2
MW:249.7377
EINECS:
Product Categories:
Mol File:Mol File
Propenyl-L-NIO (hydrochloride) Structure
Propenyl-L-NIO (hydrochloride) Chemical Properties
solubility DMF: 2.5 mg/ml
DMSO: 2 mg/ml
Ethanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
Safety Information
MSDS Information
Propenyl-L-NIO (hydrochloride) Usage And Synthesis
DescriptionPropenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics.1 However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS over nNOS or eNOS. This selectivity results from iNOS exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS.1 Ki values for ENIPO binding to iNOS and nNOS are 0.56 and 6 µM, respectively.1 Accurate determination of the Ki value of ENIPO for eNOS has not been determined but is expected to be 50-fold less than iNOS.1WARNING This product is not for human or veterinary use.
References[1] LYNN E BRETSCHER. Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines.[J]. The Journal of Biological Chemistry, 2003, 278 47: 46789-46797. DOI: 10.1074/jbc.m306787200
Propenyl-L-NIO (hydrochloride) Preparation Products And Raw materials
Tag:Propenyl-L-NIO (hydrochloride) Related Product Information
L-N5-(1-Iminopropyl) ornithine (hydrochloride) Ng-monomethyl-L-arginine acetate Vinyl-L-NiO hydrochloride L-NiO dihydrochloride Ethyl-L-NiO (hydrochloride)