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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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sales@glpbio.cn |
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Product Name:PtdIns-(1,2-dioctanoyl) (sodium salt)
CAS:899827-36-2
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
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Product Name:PtdIns-(1,2-dioctanoyl) sodium salt
CAS:899827-36-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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021-69568360 18916172912 |
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order@med-bio.cn |
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Product Name:PtdIns-(1,2-dioctanoyl) (sodium salt)
CAS:899827-36-2
Purity:98% Package:1mg; 100ug; 500ug Remarks:Medbio
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 15002144251 |
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marketing@tsbiochem.com |
| Products Intro: |
Product Name:PtdIns-(1,2-dioctanoyl) (sodium salt)
CAS:899827-36-2
Package:1mg/RMB 12300
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PtdIns-(1,2-dioctanoyl) (sodium salt) manufacturers
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| | PtdIns-(1,2-dioctanoyl) (sodium salt) Basic information |
| | PtdIns-(1,2-dioctanoyl) (sodium salt) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A lyophilized powder |
| | PtdIns-(1,2-dioctanoyl) (sodium salt) Usage And Synthesis |
| Description | The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog, compared to naturally-occurring PtdIns, gives it different physical properties including high solubility in aqueous media. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade. | | Uses | Phosphatidylinositol-1,2-dioctanoyl sodium significantly inhibits transmembrane P-gp transport in a reproducible, cell line-independent, and substrate-independent manner. Phosphatidylinositol-1,2-dioctanoyl sodium plays an important role in signal transduction and cell movement[1]. | | References | 1. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins Annu. Rev. Pharmacol. Toxicol. 36,481-509(1996).
2. Majerus, P.W. Inositol phosphate biochemistry Annu. Rev. Biochem. 61,225-250(1992). |
| | PtdIns-(1,2-dioctanoyl) (sodium salt) Preparation Products And Raw materials |
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