6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate CAS#: 288628-05-7

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

生物活性靶点体外研究体内研究用途与合成方法 MSDS 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate价格(试剂级) 上下游产品信息

中文名称	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
中文同义词	6-氧代-6,7,8,9,10,11-六氢环庚[C] [1]苯并吡喃-3-基磺酸盐;化合物IROSUSTAT;6-氧代-6,7,8,9,10,11-六氢环庚并[C]苯并吡喃-3-基氨基磺酸酯;化合物IROSUSTAT,10 MM DMSO 溶液;化合物:Irosustat (STX64) CAS:288628-05-7;化合物：Irosustat (STX64) CAS:288628-05-7
英文名称	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
英文同义词	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate;BN 83495;Irosustat;STX 64;6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate;DSLPMJSGSBLWRE-UHFFFAOYSA-N;STX64 - BN83495 \| Irosustat \| 667 Coumate;COUMATE. Irosustat.
CAS号	288628-05-7
分子式	C14H15NO5S
分子量	309.34
EINECS号	604-604-1
相关类别
Mol文件	288628-05-7.mol
结构式

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate 性质

熔点	170.1-173.4 °C
沸点	544.1±60.0 °C(Predicted)
密度	1.48±0.1 g/cm3(Predicted)
储存条件	2-8°C
溶解度	二甲基亚砜：>20mg/mL
形态	白色粉末
酸度系数(pKa)	8.26±0.70(Predicted)
颜色	白色至米白色
InChI	1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChIKey	DSLPMJSGSBLWRE-UHFFFAOYSA-N
SMILES	NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate 用途与合成方法

生物活性

Irosustat (STX64, BN83495)是一种具有口服活性的、不可逆的类固醇硫酸酯酶 (steroid sulfatase)抑制剂。

靶点

Target	Value
STS ()	8 nM

体外研究

Irosustat (667 COUMATE) is a potent steroid sulfatase inhibitor, with an IC ₅₀ of 8 nM. Irosustat (667 COUMATE) inhibits steroid sulphatase (STS) activity in MCF-7 cells with an IC ₅₀ of 0.2 nM, but has no effect on the morphology or proliferation of MCF-7 cells at 10 μM.

体内研究

Irosustat potently inhibits rat liver, with inhibition of >90% when at a 1 mg/kg concentration. Irosustat (2 mg/kg, p.o. for 5 d) blocks the uterine growth stimulated by oestrone sulfate (E1S) in ovariectomized rats. In addition, Irosustat (2, 10 mg/kg, p.o.) plus E1S dose-dependently decreases the growth of NMU-induced mammary tumors in ovariectomized rats. Irosustat (667 COUMATE; 10 mg/kg, p.o.) shows 97.9 ± 0.06% inhibition on steroid sulphatase (STS) activity in rat liver.

安全信息

WGK Germany	3
存储类别	11 - 可燃固体

MSDS信息

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-14586	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat	288628-05-7	1 mg	434元
2025/12/22	HY-14586	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat	288628-05-7	10 mM * 1 mLin DMSO	681元

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate