6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Suppliers list

Company Name:	SembCorp Shenzhenshibai a Biotechnology Co., Ltd
Tel:	13412890622
Email:

Company Name:	Finetech Industry Limited
Tel:	027-87465837 19945049750
Email:	sales@finetechnology-ind.com

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate manufacturers

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Basic information

Product Name:	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
Synonyms:	6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate;BN 83495;STX 64;6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate;DSLPMJSGSBLWRE-UHFFFAOYSA-N;STX64 - BN83495 \| Irosustat \| 667 Coumate;COUMATE. Irosustat.;ST-64667
CAS:	288628-05-7
MF:	C14H15NO5S
MW:	309.34
EINECS:	604-604-1
Product Categories:
Mol File:	288628-05-7.mol

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Chemical Properties

Melting point	170.1-173.4 °C
Boiling point	544.1±60.0 °C(Predicted)
density	1.48±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
form	white powder
pka	8.26±0.70(Predicted)
color	White to off-white
InChI	1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChIKey	DSLPMJSGSBLWRE-UHFFFAOYSA-N
SMILES	NS(=O)(=O)Oc1ccc2C3=C(CCCCC3)C(=O)Oc2c1

Safety Information

WGK Germany	3
Storage Class	11 - Combustible Solids

MSDS Information

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Usage And Synthesis

Uses	STX64 is a potent, irreversible inhibitor of steroid sulfatase.
Biochem/physiol Actions	STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.
in vivo	Irosustat potently inhibits rat liver, with inhibition of >90% when at a 1 mg/kg concentration. Irosustat (2 mg/kg, p.o. for 5 d) blocks the uterine growth stimulated by oestrone sulfate (E1S) in ovariectomized rats. In addition, Irosustat (2, 10 mg/kg, p.o.) plus E1S dose-dependently decreases the growth of NMU-induced mammary tumors in ovariectomized rats^[1]. Irosustat (667 COUMATE; 10 mg/kg, p.o.) shows 97.9 ± 0.06% inhibition on steroid sulphatase (STS) activity in rat liver^[2].
storage	Store at -20°C

6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Preparation Products And Raw materials

Tag:6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate(288628-05-7) Related Product Information

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