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2-Methoxy-6-nitrophenol manufacturers
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| | 2-Methoxy-6-nitrophenol Basic information |
| Product Name: | 2-Methoxy-6-nitrophenol | | Synonyms: | Phenol, 2-methoxy-6-nitro-;6-methoxy-2-nitrophenol;Opicapone Impurity 21;2-Methoxy-6-nitropheno;2-Methoxy-6-nitrophenol | | CAS: | 15969-08-1 | | MF: | C7H7NO4 | | MW: | 169.13 | | EINECS: | | | Product Categories: | | | Mol File: | 15969-08-1.mol |  |
| | 2-Methoxy-6-nitrophenol Chemical Properties |
| Melting point | 62 °C (sublm) | | Boiling point | 260.3±20.0 °C(Predicted) | | density | 1.367±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 7.09±0.24(Predicted) | | Appearance | Yellow to orange Solid |
| | 2-Methoxy-6-nitrophenol Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-methoxy-3-nitrophenol and 6-methoxy-2-nitrophenol from guaiacol: Fuming HNO3 (0.34 mL, 0.008 mmol) was slowly added dropwise to a solution of 2-methoxyphenol (0.886 mL, 0.008 mmol) dissolved in anhydrous dichloromethane (10 mL) at -20 °C. The reaction mixture was stirred continuously for 2 hours at room temperature. Subsequently, the reaction mixture was concentrated under reduced pressure to remove the solvent. Separation by column chromatography (eluent ratio 10-30% ethyl acetate/hexane) afforded the target products 2-methoxy-3-nitrophenol (400 mg, 29% yield) and 6-methoxy-2-nitrophenol (400 mg, 29% yield). | | References | [1] Patent: US2007/93477, 2007, A1. Location in patent: Page/Page column 27 |
| | 2-Methoxy-6-nitrophenol Preparation Products And Raw materials |
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