7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl

7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl Suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	Ascent Scientific
Tel:	4401179829988
Email:	customerservice@ascentscientific.co.uk

Company Name:	Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel:	0731-85526065 13308475853
Email:	ivy@hnhbsj.com

7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl manufacturers

7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl Basic information

Product Name:	7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl
Synonyms:	7-CHLOROKYNURENIC ACID HYDROCHLORIDE;7-CL-KYNA;7-Chloro-4-hydroxyquinoline-2-carboxylic acid, 7-Cl-KYNA;7-Chloro-4-hydroxy-2-quinolinecarboxylic acid;7-Chloroquinurenic acid;7-CKA;7-chloro-4-keto-1H-quinoline-2-carboxylic acid;7-chloro-4-oxo-1H-quinoline-2-carboxylic acid
CAS:	18000-24-3
MF:	C10H6ClNO3
MW:	223.61
EINECS:	241-913-6
Product Categories:	pharmacetical;Glutamate;Glutamate receptor
Mol File:	18000-24-3.mol

7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl Chemical Properties

Melting point	277-278 °C (decomp)
Boiling point	461.5±45.0 °C(Predicted)
density	1.600±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	0.1 M NaOH: 13.7 mg/mL
form	solid
pka	0.90±0.30(Predicted)
color	tan
CAS DataBase Reference	18000-24-3(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl Usage And Synthesis

Target	Ki: 0.59 μM (reuptake of glutamate) IC50: 0.56 μM (Glycine B coagonist site of NMDA receptor)
Uses	NMDA receptor antagonist at the glycine site
Definition	ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Biological Functions	Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biological Activity	NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo	Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
storage	Room temperature

7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl Preparation Products And Raw materials

Tag:7-Chloro-4-hydroxyquinoline-2-carboxylic acid HCl(18000-24-3) Related Product Information

Trichloroisocyanuric acid Methyl 7-chloro-4-hydroxyquinoline-2-carboxylate 5,7-Dichloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester 5,7-Dichlorokynurenic acid 5-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL 7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL DICHLOROKYNURENIC ACID, 5,7-[3-3H]-