RP107

Request For Quotation
RP107 Suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532 18210857532
Email: jkinfo@jkchemical.com
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: Shanghai Paulshine Chemical Co., Ltd.  
Tel: +86-021-37788663
Email:
Company Name: Chemsky（shanghai）International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Company Name: SynAsst Chemical.  
Tel: 021-60343070
Email:

RP107 manufacturers

  • Aloisine A
  • Aloisine A pictures
  • $2500.00
  • 2026-07-27
  • CAS:496864-16-5
  • Purity:
  • Supply Ability: 10g
  • Aloisine A
  • Aloisine A pictures
  • 2026-07-15
  • CAS:496864-16-5
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 20Tons
RP107 Basic information
Product Name:RP107
Synonyms:RP107;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;ALOISINE A;ALOISINE A RP107;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE;RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine;RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine
CAS:496864-16-5
MF:C16H17N3O
MW:267.33
EINECS:
Product Categories:All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Aromatics;Heterocycles
Mol File:496864-16-5.mol
RP107 Structure
RP107 Chemical Properties
Melting point 281-283°C
density 1.227
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Yellow solid
pka9.67±0.15(Predicted)
color Light Orangish Yellow
InChI1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
InChIKeyPRIGRJPRGZCFAS-UHFFFAOYSA-N
SMILES[nH]1c2nccnc2c(c1c3ccc(cc3)O)CCCC
Safety Information
Risk Statements 36/37/38
Safety Statements 26-36/37
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
RP107 Usage And Synthesis
Chemical PropertiesYellow solid
UsesA cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,
DefinitionChEBI: 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)-1-cyclohexa-2,5-dienone is a member of quinomethanes.
General DescriptionA cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC50 = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC50 = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC50 = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC50 ≥ 100 μM). Shown to arrest cells in both G1 and G2 phases (IC50 = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC50 = 150 nM, 140 nM and 111 nM, respectively).
Biochem/physiol ActionsEC50 = 150 nM, 140 nM and 111 nM, in stimulating CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin, respectively
RP107 Preparation Products And Raw materials
Tag:RP107(496864-16-5) Related Product Information
Indirubin-3'-oxime tert-Butyl methyl ether Indirubin (S)-CR8 KENPAULLONE Alsterpaullone 2-Phenyl-4,7-diazaindole Thr-Arg-Ser-Ala-Trp H-Thr-Arg-Ser-Ala-Trp-NH2 RP107 RP106