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VE 822

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Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:VE 822
CAS:1232416-25-9
Purity:99% Package:1kg;2USD
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
Tel: +86-18530059196
Email: sale04@alfachem.cn
Products Intro: CAS:1232416-25-9
Purity:97%+ Package:5g;25g;100g;500g;1kg;25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Berzosertib
CAS:1232416-25-9
Purity:99.7% Package:1mg;30USD|5mg;68USD|10mg;93USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:VE 822
CAS:1232416-25-9
Purity:41499% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1059@dideu.com
Products Intro: Product Name:VE 822
CAS:1232416-25-9
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

VE 822 manufacturers

  • VE 822
  • VE 822 pictures
  • 2026-06-30
  • CAS:1232416-25-9
  • Min. Order: 1KG
  • Purity: 98.0%
  • Supply Ability: 10000KGS
  • Berzosertib
  • Berzosertib pictures
  • $30.00
  • 2026-05-11
  • CAS:1232416-25-9
  • Purity: 99.61%
  • Supply Ability: 10g
  • VE 822
  • VE 822 pictures
  • $2.00
  • 2019-07-06
  • CAS:1232416-25-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
VE 822 Basic information
Product Name:VE 822
Synonyms:VX970 (VE-822);2-Pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-;3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine VE-822;VE 822 3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine;VE 822;3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine;VE822; VE 822;CS-1487
CAS:1232416-25-9
MF:C24H25N5O3S
MW:463.55
EINECS:1592732-453-0
Product Categories:Inhibitors
Mol File:1232416-25-9.mol
VE 822 Structure
VE 822 Chemical Properties
Melting point >197°C (dec.)
Boiling point 674.4±55.0 °C(Predicted)
density 1.263±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka8.88±0.10(Predicted)
form Solid
color Light Yellow
InChIKeyJZCWLJDSIRUGIN-UHFFFAOYSA-N
SMILESC1(N)=NC=C(C2=CC=C(S(C(C)C)(=O)=O)C=C2)N=C1C1ON=C(C2=CC=C(CNC)C=C2)C=1
Safety Information
MSDS Information
VE 822 Usage And Synthesis
Uses3-[3-[4-[(Methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine is a novel ATR (ATM-Rad3-related) inhibitor for in vitro and in vivo radiosensatization.
DefinitionChEBI: 3-[3-[4-(methylaminomethyl)phenyl]-5-isoxazolyl]-5-(4-propan-2-ylsulfonylphenyl)-2-pyrazinamine is a sulfonamide.
in vivo

PSN-1 xenografts are treated with Berzosertib (VE-822) (60 mk/kg; d0, 1), NSC 613327 (100 mg/kg; d0) and/or XRT (6 Gy; d1). Tumors are then harvested 2 h post-XRT. Berzosertib (VE-822) inhibits p-Ser-345-Chk1 in xenografts after DNA-damaging agents, establishing VE-822 as a potent inhibitor of ATR in vivo. Besides, Berzosertib (VE-822) enhances the therapeutic efficacy of radiation (XRT) in MiaPaCa-2 and PSN-1 xenograft models[1].

IC 50ATR: 0.2 nM (Ki); ATM: 34 nM (Ki); PI3Kγ: 220 nM (Ki)
VE 822 Preparation Products And Raw materials
Tag:VE 822(1232416-25-9) Related Product Information
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