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DuocarMycin manufacturers
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| | DuocarMycin Basic information |
| Product Name: | DuocarMycin | | Synonyms: | DuocarMycin;Duocarmycin DM free base;Methanone, [(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-3H-benz[e]indol-3-yl][5-[2-(dimethylamino)ethoxy]-1H-indol-2-yl]- | | CAS: | 1116745-06-2 | | MF: | C26H26ClN3O3 | | MW: | 463.96 | | EINECS: | | | Product Categories: | | | Mol File: | 1116745-06-2.mol |  |
| | DuocarMycin Chemical Properties |
| Boiling point | 712.9±60.0 °C(Predicted) | | density | 1.345±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.47±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | DuocarMycin Usage And Synthesis |
| Uses | Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2]. | | IC 50 | Daunorubicins/Doxorubicins | | References | [1] Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-630. DOI:10.2174/1871520615666141216144116
[2] Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4. DOI:10.1002/anie.201505749
[3] Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782. DOI:10.1021/mp300581u
[4] Chen KC, Schmuck K, Tietze LF, Roffler SR. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782. DOI:10.1021/mp300581u |
| | DuocarMycin Preparation Products And Raw materials |
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